Affinity Data by PubMed id=30940566

PubMed code 30940566

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523945 (CHEMBL4475926) Show SMILES Cc1cc(C)n(c(=O)n1)S(=O)(=O)c1ccc(N)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	3.66E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523946 (ONO-1078) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	Article PubMed	1.27E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523945 (CHEMBL4475926) Show SMILES Cc1cc(C)n(c(=O)n1)S(=O)(=O)c1ccc(N)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523946 (ONO-1078) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50001908 (1-(4-Nitro-phenyl)-piperazine \| CHEMBL165012) Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCNCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523947 (CHEMBL4447423) Show SMILES Nc1ccc(cn1)[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.37E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523948 (CHEBI:78878 \| CHEMBL1743207) Show SMILES [O-][N+](=O)c1ccc(Cl)c2nonc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.41E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523949 (4-Nitrocatechol \| CHEBI:16318) Show SMILES Oc1ccc(cc1O)[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50192743 (3,4-Dihydroxybenzaldehyde \| CHEBI:50205 \| PROTOCAT...) Show SMILES Oc1ccc(C=O)cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.39E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50103596 ((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523950 (CHEMBL1368663) Show SMILES COCC(=O)\C=C1/Sc2ccccc2N1C Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523944 (CHEMBL4544405) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523946 (ONO-1078) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50523945 (CHEMBL4475926) Show SMILES Cc1cc(C)n(c(=O)n1)S(=O)(=O)c1ccc(N)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM97231 (2-[(E)-2-(4-morpholin-4-ylphenyl)ethenyl]quinoline...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50192743 (3,4-Dihydroxybenzaldehyde \| CHEBI:50205 \| PROTOCAT...) Show SMILES Oc1ccc(C=O)cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (Middle East respiratory syndrome-related coronavir...)	BDBM50384265 (CHEMBL2030452) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to MERS-CoV papain-like protease by SPR analysis				Bioorg Med Chem 27: 1981-1989 (2019) Article DOI: 10.1016/j.bmc.2019.03.050
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%