Affinity Data by PubMed id=31284084

PubMed code 31284084

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50502464 (CHEMBL1443979) Show SMILES FC(F)(F)c1cc(nc(NCc2cccs2)n1)-c1ccco1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...				Eur J Med Chem 179: 744-752 (2019) Article DOI: 10.1016/j.ejmech.2019.06.084
Freie Universit£t Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50502465 (CHEMBL1401818) Show SMILES FC(F)(F)c1cc(nc(NCc2cccs2)n1)-c1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...				Eur J Med Chem 179: 744-752 (2019) Article DOI: 10.1016/j.ejmech.2019.06.084
Freie Universit£t Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50502466 (CHEMBL4589214) Show SMILES CCCCNc1nc(cc(n1)C(F)(F)F)-c1cccs1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...				Eur J Med Chem 179: 744-752 (2019) Article DOI: 10.1016/j.ejmech.2019.06.084
Freie Universit£t Berlin Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%