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PubMed code 31284084

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50502464
PNG
(CHEMBL1443979)
Show SMILES FC(F)(F)c1cc(nc(NCc2cccs2)n1)-c1ccco1
Show InChI InChI=1S/C14H10F3N3OS/c15-14(16,17)12-7-10(11-4-1-5-21-11)19-13(20-12)18-8-9-3-2-6-22-9/h1-7H,8H2,(H,18,19,20)
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UniChem
Article
PubMed
n/an/a 9.20E+3n/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...


Eur J Med Chem 179: 744-752 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.084
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50502465
PNG
(CHEMBL1401818)
Show SMILES FC(F)(F)c1cc(nc(NCc2cccs2)n1)-c1ccccc1
Show InChI InChI=1S/C16H12F3N3S/c17-16(18,19)14-9-13(11-5-2-1-3-6-11)21-15(22-14)20-10-12-7-4-8-23-12/h1-9H,10H2,(H,20,21,22)
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UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...


Eur J Med Chem 179: 744-752 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.084
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50502466
PNG
(CHEMBL4589214)
Show SMILES CCCCNc1nc(cc(n1)C(F)(F)F)-c1cccs1
Show InChI InChI=1S/C13H14F3N3S/c1-2-3-6-17-12-18-9(10-5-4-7-20-10)8-11(19-12)13(14,15)16/h4-5,7-8H,2-3,6H2,1H3,(H,17,18,19)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.55E+4n/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NF-kappaB activation incubated for 1 hr followe...


Eur J Med Chem 179: 744-752 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.084
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%