Affinity Data by PubMed id=32253226

PubMed code 32253226

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Replicase polyprotein 1ab (2019-nCoV)	BDBM430624 (Beta-D-N4-hydroxycytidine \| EIDD-1931 \| N(4)-Hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	Purchase UniChem	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37�C. Plates were manually rocked every 10 min ...				Sci Transl Med 12: 1-15 (2020) Article DOI: 10.1126/scitranslmed.abb5883 BindingDB Entry DOI: 10.7270/Q26D5WDN
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM430624 (Beta-D-N4-hydroxycytidine \| EIDD-1931 \| N(4)-Hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	Purchase UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37�C. Plates were manually rocked every 10 min ...				Sci Transl Med 12: 1-15 (2020) Article DOI: 10.1126/scitranslmed.abb5883 BindingDB Entry DOI: 10.7270/Q26D5WDN
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
3C-like proteinase (MERS-CoV)	BDBM430624 (Beta-D-N4-hydroxycytidine \| EIDD-1931 \| N(4)-Hydro...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL GoogleScholar	Purchase UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...				Sci Transl Med 12: 1-15 (2020) Article DOI: 10.1126/scitranslmed.abb5883 BindingDB Entry DOI: 10.7270/Q26D5WDN
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM430624 (Beta-D-N4-hydroxycytidine \| EIDD-1931 \| N(4)-Hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	Purchase UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill					Assay Description Vero E6 cells were plated at 20,000 cells/well in a 96-well plate. 24hr later, medium containing a dose response of NHC was added concurrent with SAR...				Sci Transl Med 12: 1-15 (2020) Article DOI: 10.1126/scitranslmed.abb5883 BindingDB Entry DOI: 10.7270/Q26D5WDN
University of North Carolina at Chapel Hill					More data for this Ligand-Target Pair

* indicates data uncertainty>20%