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Found 26 Enz. Inhib. hit(s) with all data for entry = 50031677
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317108(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304619((S)-2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)-2-hy...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human factor 10a using S2222 as substrate after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317107(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317096(4-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50270656(2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)propanoyl...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304620(2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)propanoyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317095(1'-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-h...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317092(1-(1-{3-[(6-Chloronaphthalen-2-yl)sulfonyl]propano...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317101(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317097(3-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50304621((R)-2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)-2-hy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317104(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317106((7aS)-2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfo...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317093(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317103(1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317094(2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317105((7aR)-2-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfo...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317102(3-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317099((2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-oxo-1...)
Affinity DataIC50:  147nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317100((2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-1-[4-(1...)
Affinity DataIC50:  198nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human thrombin after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human factor 9a after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human tissue plasminogen activator after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of human plasmin after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed