Compile Data Set for Download or QSAR
maximum 50k data
Found 31 Enz. Inhib. hit(s) with all data for entry = 50032192
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325767(3-(2'-chlorobiphenyl-3-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325766(3-(2'-chlorobiphenyl-4-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325765(3-(4-(4-chloro-2-fluorophenoxy)phenyl)-1H-pyrazole...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325779(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325769(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325778(1-(2'-fluoro-6'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325770(5-amino-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325781(5-methyl-1-(2'-(2,2,3,3,3-pentafluoropropoxy)biphe...)
Affinity DataIC50:  128nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325782(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50:  162nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325774(5-methyl-1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  163nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325780(5-methyl-1-(2'-(2,2,2-trifluoroethoxy)biphenyl-3-y...)
Affinity DataIC50:  187nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325783(1-(4-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50:  222nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325776(1-(4'-chloro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  243nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325784(1-(2',6-bis(trifluoromethoxy)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  373nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325777(1-(5'-fluoro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  412nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  426nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325768(3-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  508nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325773(1-(2'-chlorobiphenyl-3-yl)-5-methyl-1H-pyrazole-3-...)
Affinity DataIC50:  738nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325775(1-(3'-fluoro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  781nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325785(5-methyl-1-(2'-phenoxybiphenyl-3-yl)-1H-pyrazole-3...)
Affinity DataIC50:  875nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325772(5-tert-butyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: >2.50E+4nMAssay Description:Induction of human PXR by induction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed