Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 50005495
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50007164((S)-1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(...)
Affinity DataKi:  0.640nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037595(1-((S)-2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(...)
Affinity DataKi:  0.810nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM83436(2-(3,4-dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-(1...)
Affinity DataKi:  1.10nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037578(6-(2-{(S)-2-[(Isopropyl-methyl-amino)-methyl]-pipe...)
Affinity DataKi:  4.07nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037586(2-[2-Oxo-2-((S)-2-pyrrolidin-1-ylmethyl-piperidin-...)
Affinity DataKi:  5.44nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037582(7-[2-Oxo-2-((S)-2-pyrrolidin-1-ylmethyl-piperidin-...)
Affinity DataKi:  5.61nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037592(6-(2-{(S)-2-[(Methyl-prop-2-ynyl-amino)-methyl]-pi...)
Affinity DataKi:  6.24nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037594(2-[2-Oxo-2-((S)-2-pyrrolidin-1-ylmethyl-piperidin-...)
Affinity DataKi:  6.54nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037577(6-[2-Oxo-2-((S)-2-pyrrolidin-1-ylmethyl-piperidin-...)
Affinity DataKi:  7.60nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037590(5-[2-Oxo-2-((S)-2-pyrrolidin-1-ylmethyl-piperidin-...)
Affinity DataKi:  7.93nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037591(6-(2-{(S)-2-[(Ethyl-methyl-amino)-methyl]-piperidi...)
Affinity DataKi:  10.3nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037589(6-(2-{(S)-2-[(Allyl-methyl-amino)-methyl]-piperidi...)
Affinity DataKi:  19.2nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037583(6-(2-{(S)-2-[(Cyclopentyl-methyl-amino)-methyl]-pi...)
Affinity DataKi:  20nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037579(6-(2-{(S)-2-[(Methyl-propyl-amino)-methyl]-piperid...)
Affinity DataKi:  22.2nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037593(6-(2-{(S)-2-[(Cyclopropylmethyl-methyl-amino)-meth...)
Affinity DataKi:  30.4nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037584(6-(2-{(S)-2-[(Cyclobutyl-methyl-amino)-methyl]-pip...)
Affinity DataKi:  34.8nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037581(6-[2-((S)-2-Dimethylaminomethyl-piperidin-1-yl)-2-...)
Affinity DataKi:  47nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037580(6-(2-{(S)-2-[(Cyclopropyl-methyl-amino)-methyl]-pi...)
Affinity DataKi:  52.1nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037588(6-[2-((S)-2-Diethylaminomethyl-piperidin-1-yl)-2-o...)
Affinity DataKi:  80.3nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037581(6-[2-((S)-2-Dimethylaminomethyl-piperidin-1-yl)-2-...)
Affinity DataKi: >100nMAssay Description:Evaluated for the binding affinity at delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037585(6-(2-{(S)-2-[(tert-Butyl-methyl-amino)-methyl]-pip...)
Affinity DataKi: >100nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  301nMAssay Description:Evaluated for the binding affinity at kappa receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037581(6-[2-((S)-2-Dimethylaminomethyl-piperidin-1-yl)-2-...)
Affinity DataKi:  1.21E+3nMAssay Description:Evaluated for the binding affinity at sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Smithkline Beecham Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50037581(6-[2-((S)-2-Dimethylaminomethyl-piperidin-1-yl)-2-...)
Affinity DataKi:  6.79E+3nMAssay Description:Evaluated for the binding affinity at mu receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed