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PubMed code 8057278

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037171
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-methyl-2,3-dihydr...)
Show SMILES CN1CCc2cc(ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C24H30N2O/c1-25-14-13-21-17-22(8-9-23(21)25)24(27)10-7-19-11-15-26(16-12-19)18-20-5-3-2-4-6-20/h2-6,8-9,17,19H,7,10-16,18H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037173
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-ethyl-2,3-dihydro...)
Show SMILES CCN1CCc2cc(ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H32N2O/c1-2-27-17-14-22-18-23(9-10-24(22)27)25(28)11-8-20-12-15-26(16-13-20)19-21-6-4-3-5-7-21/h3-7,9-10,18,20H,2,8,11-17,19H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039226
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(3-fluoro-benzy...)
Show SMILES Fc1cccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)c1
Show InChI InChI=1S/C23H27FN2O/c24-21-3-1-2-18(14-21)16-26-12-9-17(10-13-26)4-7-23(27)20-5-6-22-19(15-20)8-11-25-22/h1-3,5-6,14-15,17,25H,4,7-13,16H2
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n/an/a 16n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037138
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(2,3-dihydro-1H-indo...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2NCCc2c1
Show InChI InChI=1S/C23H28N2O/c26-23(21-7-8-22-20(16-21)10-13-24-22)9-6-18-11-14-25(15-12-18)17-19-4-2-1-3-5-19/h1-5,7-8,16,18,24H,6,9-15,17H2
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n/an/a 20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037141
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-propyl-2,3-dihydr...)
Show SMILES CCCN1CCc2cc(ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C26H34N2O/c1-2-15-28-18-14-23-19-24(9-10-25(23)28)26(29)11-8-21-12-16-27(17-13-21)20-22-6-4-3-5-7-22/h3-7,9-10,19,21H,2,8,11-18,20H2,1H3
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n/an/a 22n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039210
PNG
(3-[1-(3-Chloro-benzyl)-piperidin-4-yl]-1-(1-methyl...)
Show SMILES CN1CCCc2cc(ccc12)C(=O)CCC1CCN(Cc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C25H31ClN2O/c1-27-13-3-5-21-17-22(8-9-24(21)27)25(29)10-7-19-11-14-28(15-12-19)18-20-4-2-6-23(26)16-20/h2,4,6,8-9,16-17,19H,3,5,7,10-15,18H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039222
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-butyl-2,3-dihydro...)
Show SMILES CCCCN1CCc2cc(ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H36N2O/c1-2-3-16-29-19-15-24-20-25(10-11-26(24)29)27(30)12-9-22-13-17-28(18-14-22)21-23-7-5-4-6-8-23/h4-8,10-11,20,22H,2-3,9,12-19,21H2,1H3
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n/an/a 29n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039212
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-methyl-1,2,3,4-te...)
Show SMILES CN1CCCc2ccc(cc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H32N2O/c1-26-15-5-8-22-10-11-23(18-24(22)26)25(28)12-9-20-13-16-27(17-14-20)19-21-6-3-2-4-7-21/h2-4,6-7,10-11,18,20H,5,8-9,12-17,19H2,1H3
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n/an/a 36n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039227
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(2-fluoro-benzy...)
Show SMILES Fc1ccccc1CN1CCC(CCC(=O)c2ccc3NCCc3c2)CC1
Show InChI InChI=1S/C23H27FN2O/c24-21-4-2-1-3-20(21)16-26-13-10-17(11-14-26)5-8-23(27)19-6-7-22-18(15-19)9-12-25-22/h1-4,6-7,15,17,25H,5,8-14,16H2
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n/an/a 43n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039231
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-pentyl-2,3-dihydr...)
Show SMILES CCCCCN1CCc2cc(ccc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H38N2O/c1-2-3-7-17-30-20-16-25-21-26(11-12-27(25)30)28(31)13-10-23-14-18-29(19-15-23)22-24-8-5-4-6-9-24/h4-6,8-9,11-12,21,23H,2-3,7,10,13-20,22H2,1H3
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n/an/a 47n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039223
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(3-methyl-benzy...)
Show SMILES Cc1cccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)c1
Show InChI InChI=1S/C24H30N2O/c1-18-3-2-4-20(15-18)17-26-13-10-19(11-14-26)5-8-24(27)22-6-7-23-21(16-22)9-12-25-23/h2-4,6-7,15-16,19,25H,5,8-14,17H2,1H3
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n/an/a 50n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039213
PNG
(3-[1-(3-Chloro-benzyl)-piperidin-4-yl]-1-(1,2,3,4-...)
Show SMILES Clc1cccc(CN2CCC(CCC(=O)c3ccc4NCCCc4c3)CC2)c1
Show InChI InChI=1S/C24H29ClN2O/c25-22-5-1-3-19(15-22)17-27-13-10-18(11-14-27)6-9-24(28)21-7-8-23-20(16-21)4-2-12-26-23/h1,3,5,7-8,15-16,18,26H,2,4,6,9-14,17H2
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n/an/a 54n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039206
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1,2,3,4-tetrahydro-...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCNc2c1
Show InChI InChI=1S/C24H30N2O/c27-24(22-10-9-21-7-4-14-25-23(21)17-22)11-8-19-12-15-26(16-13-19)18-20-5-2-1-3-6-20/h1-3,5-6,9-10,17,19,25H,4,7-8,11-16,18H2
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n/an/a 54n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039204
PNG
(3-(1-(3-chlorobenzyl)piperidin-4-yl)-1-(indolin-5-...)
Show SMILES Clc1cccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)c1
Show InChI InChI=1S/C23H27ClN2O/c24-21-3-1-2-18(14-21)16-26-12-9-17(10-13-26)4-7-23(27)20-5-6-22-19(15-20)8-11-25-22/h1-3,5-6,14-15,17,25H,4,7-13,16H2
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n/an/a 59n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039230
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(3-nitro-benzyl...)
Show SMILES [O-][N+](=O)c1cccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)c1
Show InChI InChI=1S/C23H27N3O3/c27-23(20-5-6-22-19(15-20)8-11-24-22)7-4-17-9-12-25(13-10-17)16-18-2-1-3-21(14-18)26(28)29/h1-3,5-6,14-15,17,24H,4,7-13,16H2
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037140
PNG
(1-(1-Benzyl-2,3-dihydro-1H-indol-5-yl)-3-(1-benzyl...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2N(Cc3ccccc3)CCc2c1
Show InChI InChI=1S/C30H34N2O/c33-30(14-11-24-15-18-31(19-16-24)22-25-7-3-1-4-8-25)28-12-13-29-27(21-28)17-20-32(29)23-26-9-5-2-6-10-26/h1-10,12-13,21,24H,11,14-20,22-23H2
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n/an/a 68n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039215
PNG
(3-(1-(2-chlorobenzyl)piperidin-4-yl)-1-(indolin-5-...)
Show SMILES Clc1ccccc1CN1CCC(CCC(=O)c2ccc3NCCc3c2)CC1
Show InChI InChI=1S/C23H27ClN2O/c24-21-4-2-1-3-20(21)16-26-13-10-17(11-14-26)5-8-23(27)19-6-7-22-18(15-19)9-12-25-22/h1-4,6-7,15,17,25H,5,8-14,16H2
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n/an/a 76n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037150
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-methyl-2,3,4,5-te...)
Show SMILES CN1CCCCc2ccc(cc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C26H34N2O/c1-27-16-6-5-9-23-11-12-24(19-25(23)27)26(29)13-10-21-14-17-28(18-15-21)20-22-7-3-2-4-8-22/h2-4,7-8,11-12,19,21H,5-6,9-10,13-18,20H2,1H3
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039203
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(4-fluoro-benzy...)
Show SMILES Fc1ccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)cc1
Show InChI InChI=1S/C23H27FN2O/c24-21-5-1-18(2-6-21)16-26-13-10-17(11-14-26)3-8-23(27)20-4-7-22-19(15-20)9-12-25-22/h1-2,4-7,15,17,25H,3,8-14,16H2
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037157
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(2,3,4,5-tetrahydro-...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCNc2c1
Show InChI InChI=1S/C25H32N2O/c28-25(23-11-10-22-8-4-5-15-26-24(22)18-23)12-9-20-13-16-27(17-14-20)19-21-6-2-1-3-7-21/h1-3,6-7,10-11,18,20,26H,4-5,8-9,12-17,19H2
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n/an/a 97.7n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039229
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(2,3-dihydro-1H-indo...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCNc2c1
Show InChI InChI=1S/C23H28N2O/c26-23(21-8-7-20-10-13-24-22(20)16-21)9-6-18-11-14-25(15-12-18)17-19-4-2-1-3-5-19/h1-5,7-8,16,18,24H,6,9-15,17H2
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n/an/a 113n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039224
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(2,3,4,5-tetrahydro-...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2NCCCCc2c1
Show InChI InChI=1S/C25H32N2O/c28-25(23-10-11-24-22(18-23)8-4-5-15-26-24)12-9-20-13-16-27(17-14-20)19-21-6-2-1-3-7-21/h1-3,6-7,10-11,18,20,26H,4-5,8-9,12-17,19H2
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n/an/a 125n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039216
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1,2,3,4,5,6-hexahyd...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCCNc2c1
Show InChI InChI=1S/C26H34N2O/c29-26(24-12-11-23-9-5-2-6-16-27-25(23)19-24)13-10-21-14-17-28(18-15-21)20-22-7-3-1-4-8-22/h1,3-4,7-8,11-12,19,21,27H,2,5-6,9-10,13-18,20H2
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n/an/a 127n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039232
PNG
(3-(1-(3-fluorobenzyl)piperidin-4-yl)-1-(2,3,4,5-te...)
Show SMILES Fc1cccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)c1
Show InChI InChI=1S/C25H31FN2O/c26-23-6-3-4-20(16-23)18-28-14-11-19(12-15-28)7-10-25(29)22-9-8-21-5-1-2-13-27-24(21)17-22/h3-4,6,8-9,16-17,19,27H,1-2,5,7,10-15,18H2
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n/an/a 145n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039202
PNG
(1-(1-Benzyl-1,2,3,4-tetrahydro-quinolin-6-yl)-3-[1...)
Show SMILES Clc1cccc(CN2CCC(CCC(=O)c3ccc4N(Cc5ccccc5)CCCc4c3)CC2)c1
Show InChI InChI=1S/C31H35ClN2O/c32-29-10-4-8-26(20-29)22-33-18-15-24(16-19-33)11-14-31(35)28-12-13-30-27(21-28)9-5-17-34(30)23-25-6-2-1-3-7-25/h1-4,6-8,10,12-13,20-21,24H,5,9,11,14-19,22-23H2
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n/an/a 164n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039221
PNG
(3-(1-(3-methylbenzyl)piperidin-4-yl)-1-(2,3,4,5-te...)
Show SMILES Cc1cccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)c1
Show InChI InChI=1S/C26H34N2O/c1-20-5-4-6-22(17-20)19-28-15-12-21(13-16-28)8-11-26(29)24-10-9-23-7-2-3-14-27-25(23)18-24/h4-6,9-10,17-18,21,27H,2-3,7-8,11-16,19H2,1H3
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n/an/a 224n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 271n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039205
PNG
(3-(1-(2-fluorobenzyl)piperidin-4-yl)-1-(2,3,4,5-te...)
Show SMILES Fc1ccccc1CN1CCC(CCC(=O)c2ccc3CCCCNc3c2)CC1
Show InChI InChI=1S/C25H31FN2O/c26-23-7-2-1-6-22(23)18-28-15-12-19(13-16-28)8-11-25(29)21-10-9-20-5-3-4-14-27-24(20)17-21/h1-2,6-7,9-10,17,19,27H,3-5,8,11-16,18H2
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n/an/a 331n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039225
PNG
(3-(1-(3-chlorobenzyl)piperidin-4-yl)-1-(2,3,4,5-te...)
Show SMILES Clc1cccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)c1
Show InChI InChI=1S/C25H31ClN2O/c26-23-6-3-4-20(16-23)18-28-14-11-19(12-15-28)7-10-25(29)22-9-8-21-5-1-2-13-27-24(21)17-22/h3-4,6,8-9,16-17,19,27H,1-2,5,7,10-15,18H2
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n/an/a 333n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037183
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-ethyl-2,3,4,5-tet...)
Show SMILES CCN1CCCCc2ccc(cc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H36N2O/c1-2-29-17-7-6-10-24-12-13-25(20-26(24)29)27(30)14-11-22-15-18-28(19-16-22)21-23-8-4-3-5-9-23/h3-5,8-9,12-13,20,22H,2,6-7,10-11,14-19,21H2,1H3
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n/an/a 376n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039219
PNG
(3-(1-(3-nitrobenzyl)piperidin-4-yl)-1-(2,3,4,5-tet...)
Show SMILES [O-][N+](=O)c1cccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)c1
Show InChI InChI=1S/C25H31N3O3/c29-25(22-9-8-21-5-1-2-13-26-24(21)17-22)10-7-19-11-14-27(15-12-19)18-20-4-3-6-23(16-20)28(30)31/h3-4,6,8-9,16-17,19,26H,1-2,5,7,10-15,18H2
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n/an/a 390n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039207
PNG
(3-(1-(4-fluorobenzyl)piperidin-4-yl)-1-(2,3,4,5-te...)
Show SMILES Fc1ccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)cc1
Show InChI InChI=1S/C25H31FN2O/c26-23-9-4-20(5-10-23)18-28-15-12-19(13-16-28)6-11-25(29)22-8-7-21-3-1-2-14-27-24(21)17-22/h4-5,7-10,17,19,27H,1-3,6,11-16,18H2
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n/an/a 393n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039208
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(2-methoxy-benz...)
Show SMILES COc1ccccc1CN1CCC(CCC(=O)c2ccc3NCCc3c2)CC1
Show InChI InChI=1S/C24H30N2O2/c1-28-24-5-3-2-4-21(24)17-26-14-11-18(12-15-26)6-9-23(27)20-7-8-22-19(16-20)10-13-25-22/h2-5,7-8,16,18,25H,6,9-15,17H2,1H3
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n/an/a 812n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039228
PNG
(3-(1-(3-methoxybenzyl)piperidin-4-yl)-1-(2,3,4,5-t...)
Show SMILES COc1cccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)c1
Show InChI InChI=1S/C26H34N2O2/c1-30-24-7-4-5-21(17-24)19-28-15-12-20(13-16-28)8-11-26(29)23-10-9-22-6-2-3-14-27-25(22)18-23/h4-5,7,9-10,17-18,20,27H,2-3,6,8,11-16,19H2,1H3
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n/an/a 847n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039220
PNG
(1-(1-Benzyl-2,3-dihydro-1H-indol-6-yl)-3-(1-benzyl...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCN(Cc3ccccc3)c2c1
Show InChI InChI=1S/C30H34N2O/c33-30(14-11-24-15-18-31(19-16-24)22-25-7-3-1-4-8-25)28-13-12-27-17-20-32(29(27)21-28)23-26-9-5-2-6-10-26/h1-10,12-13,21,24H,11,14-20,22-23H2
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n/an/a 853n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037165
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-propyl-2,3,4,5-te...)
Show SMILES CCCN1CCCCc2ccc(cc12)C(=O)CCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H38N2O/c1-2-17-30-18-7-6-10-25-12-13-26(21-27(25)30)28(31)14-11-23-15-19-29(20-16-23)22-24-8-4-3-5-9-24/h3-5,8-9,12-13,21,23H,2,6-7,10-11,14-20,22H2,1H3
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n/an/a 1.33E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039211
PNG
(3-(1-Benzyl-piperidin-4-yl)-1-(1-benzyl-1,2,3,4-te...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCN(Cc3ccccc3)c2c1
Show InChI InChI=1S/C31H36N2O/c34-31(16-13-25-17-20-32(21-18-25)23-26-8-3-1-4-9-26)29-15-14-28-12-7-19-33(30(28)22-29)24-27-10-5-2-6-11-27/h1-6,8-11,14-15,22,25H,7,12-13,16-21,23-24H2
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n/an/a 1.49E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039218
PNG
(3-(1-(2-methoxybenzyl)piperidin-4-yl)-1-(2,3,4,5-t...)
Show SMILES COc1ccccc1CN1CCC(CCC(=O)c2ccc3CCCCNc3c2)CC1
Show InChI InChI=1S/C26H34N2O2/c1-30-26-8-3-2-7-23(26)19-28-16-13-20(14-17-28)9-12-25(29)22-11-10-21-6-4-5-15-27-24(21)18-22/h2-3,7-8,10-11,18,20,27H,4-6,9,12-17,19H2,1H3
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n/an/a 2.62E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039217
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(3-methoxy-benz...)
Show SMILES COc1cccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)c1
Show InChI InChI=1S/C24H30N2O2/c1-28-22-4-2-3-19(15-22)17-26-13-10-18(11-14-26)5-8-24(27)21-6-7-23-20(16-21)9-12-25-23/h2-4,6-7,15-16,18,25H,5,8-14,17H2,1H3
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n/an/a 2.68E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50037164
PNG
(1-(1-benzyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8...)
Show SMILES O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCN(Cc3ccccc3)c2c1
Show InChI InChI=1S/C32H38N2O/c35-32(17-14-26-18-21-33(22-19-26)24-27-9-3-1-4-10-27)30-16-15-29-13-7-8-20-34(31(29)23-30)25-28-11-5-2-6-12-28/h1-6,9-12,15-16,23,26H,7-8,13-14,17-22,24-25H2
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n/an/a 3.14E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039201
PNG
(3-(1-(4-chlorobenzyl)piperidin-4-yl)-1-(indolin-5-...)
Show SMILES Clc1ccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)cc1
Show InChI InChI=1S/C23H27ClN2O/c24-21-5-1-18(2-6-21)16-26-13-10-17(11-14-26)3-8-23(27)20-4-7-22-19(15-20)9-12-25-22/h1-2,4-7,15,17,25H,3,8-14,16H2
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n/an/a 6.36E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039214
PNG
(1-(2,3-Dihydro-1H-indol-5-yl)-3-[1-(4-methoxy-benz...)
Show SMILES COc1ccc(CN2CCC(CCC(=O)c3ccc4NCCc4c3)CC2)cc1
Show InChI InChI=1S/C24H30N2O2/c1-28-22-6-2-19(3-7-22)17-26-14-11-18(12-15-26)4-9-24(27)21-5-8-23-20(16-21)10-13-25-23/h2-3,5-8,16,18,25H,4,9-15,17H2,1H3
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n/an/a 1.33E+4n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50039209
PNG
(3-(1-(4-methoxybenzyl)piperidin-4-yl)-1-(2,3,4,5-t...)
Show SMILES COc1ccc(CN2CCC(CCC(=O)c3ccc4CCCCNc4c3)CC2)cc1
Show InChI InChI=1S/C26H34N2O2/c1-30-24-10-5-21(6-11-24)19-28-16-13-20(14-17-28)7-12-26(29)23-9-8-22-4-2-3-15-27-25(22)18-23/h5-6,8-11,18,20,27H,2-4,7,12-17,19H2,1H3
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n/an/a 5.52E+4n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of acetylcholinesterase (AChE)


J Med Chem 37: 2292-9 (1994)


Article DOI: 10.1021/jm00041a007
BindingDB Entry DOI: 10.7270/Q2SX6C8G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%