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Found 17 Enz. Inhib. hit(s) with all data for entry = 50005985
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043393(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataKi:  0.00365nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043396(2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-na...)
Affinity DataKi:  0.00455nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043399(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataKi:  0.00465nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.00482nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043395(2-({4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidi...)
Affinity DataKi:  0.00484nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043400(2-({4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidi...)
Affinity DataKi:  0.00508nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043398(2-({4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-...)
Affinity DataKi:  0.00520nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043394(2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-am...)
Affinity DataKi:  0.00522nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043397(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataKi:  0.0131nMAssay Description:Inhibitory activity of Dihydrofolate reductase in L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043394(2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-am...)
Affinity DataIC50:  0.000190nMAssay Description:Tested for inhibition against P. carinii DHFR (dihydrofolate reductase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043393(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataIC50:  0.000530nMAssay Description:Tested for inhibition against Dihydrofolate reductase from P. cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50016325(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataIC50:  0.000530nMAssay Description:Inhibition against Pneumocystis carinii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043393(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataIC50:  0.000530nMAssay Description:Tested for inhibition against Dihydrofolate reductase from P. cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043393(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataIC50:  0.00160nMAssay Description:Tested for inhibition against Dihydrofolate reductase from T. gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50016325(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataIC50:  0.00160nMAssay Description:Inhibition against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50016325(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataIC50:  0.00210nMAssay Description:Inhibition against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50043394(2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-am...)
Affinity DataIC50:  0.00250nMAssay Description:Tested for inhibition against rat liver DHFR (dihydrofolate reductase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed