Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 50006078
TargetAromatase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity for Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Rattus norvegicus)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50161586(4-{(2S,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  11nMAssay Description:Apparent Ki for rat Lanosterol 14-alpha demethylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  13nMAssay Description:Binding affinity for Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  15nMAssay Description:Binding affinity for corticoid 11-beta-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataKi:  25nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataKi:  28nMAssay Description:Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  33nMAssay Description:Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataKi:  35nMAssay Description:Binding affinity for corticoid 11-beta-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Rattus norvegicus)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  37nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  40nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  40.4nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  54nMAssay Description:Binding affinity for progesterone 17alpha,20-lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataKi:  64nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase in hamster hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Rattus norvegicus)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataKi:  65nMAssay Description:Inhibition of lanosterol 14-alpha-demethylase of rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044425(4-{(2R,4R)-2-[2-(4-Chloro-phenyl)-ethyl]-2-imidazo...)
Affinity DataKi:  109nMAssay Description:Binding affinity for cholesterol 17-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Rattus norvegicus)
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM31653(CHEMBL421109 | imidazole-dioxolane, 5)
Affinity DataKi:  117nMAssay Description:Apparent Ki for rat Lanosterol 14-alpha demethylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataKi:  447nMAssay Description:Binding affinity for progesterone 17-alpha,20-lyaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Syntex Discovery Research

Curated by ChEMBL
LigandPNGBDBM50044424(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Affinity DataKi:  1.63E+3nMAssay Description:Binding affinity for cholesterol 17-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed