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PubMed code 8421286

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2714
PNG
(3-[(2S)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2700
PNG
(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 7.60n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2712
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{2-[(methylamino)meth...)
Show SMILES CNCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21
Show InChI InChI=1S/C27H26N4O2/c1-28-14-16-11-12-31-21-10-6-4-8-18(21)23(22(31)13-16)25-24(26(32)29-27(25)33)19-15-30(2)20-9-5-3-7-17(19)20/h3-10,15-16,28H,11-14H2,1-2H3,(H,29,32,33)
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n/an/a 9.80n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2715
PNG
(3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2699
PNG
(3-[2-(aminomethyl)-1H,2H,3H-benzo[b]pyrrolizin-9-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(11-26)10-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 14n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2702
PNG
(3-[3-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-15(12-27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 15n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2704
PNG
(3-[8-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-12-16(14-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 16.5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2703
PNG
(3-[3-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CCN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-14-16(12-13-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 23n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2705
PNG
(3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyr...)
Show SMILES CN(C)CC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)
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n/an/a 42n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2701
PNG
(3-[2-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CCN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-11-16(10-12-28)14-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 47n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2713
PNG
(3-[6,7,8,9-Tetrahydro-8-[(trimethylamino)methyl]py...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(C[N+](C)(C)C)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C29H30N4O2/c1-31-16-21(19-9-5-7-11-22(19)31)26-27(29(35)30-28(26)34)25-20-10-6-8-12-23(20)32-14-13-18(15-24(25)32)17-33(2,3)4/h5-12,16,18H,13-15,17H2,1-4H3/p+1
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n/an/a 49n/an/an/an/an/an/a



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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
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n/an/a 75n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2710
PNG
(3-[8-Amino-7,8,9,10-tetrahydro-6H-azepino[1,2-a]in...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(N)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-12-15(27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 100n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2708
PNG
(3-{2-amino-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(N)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-11-10-14(26)12-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 110n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 121n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2709
PNG
(3-{3-amino-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(N)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(26)10-11-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 135n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2697
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{1H,2H,3H,4H-pyrido[1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c1-27-14-17(15-8-2-4-10-18(15)27)22-23(25(30)26-24(22)29)21-16-9-3-5-11-19(16)28-13-7-6-12-20(21)28/h2-5,8-11,14H,6-7,12-13H2,1H3,(H,26,29,30)
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n/an/a 155n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2696
PNG
(3-{1H,2H,3H-benzo[b]pyrrolizin-9-yl}-4-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H19N3O2/c1-26-13-16(14-7-2-4-9-17(14)26)21-22(24(29)25-23(21)28)20-15-8-3-5-10-18(15)27-12-6-11-19(20)27/h2-5,7-10,13H,6,11-12H2,1H3,(H,25,28,29)
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n/an/a 210n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2707
PNG
(3-[9-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-8-2-4-10-20(17)30)24-25(27(33)29-26(24)32)23-18-9-3-5-11-21(18)31-12-6-7-16(14-28)13-22(23)31/h2-5,8-11,15-16H,6-7,12-14,28H2,1H3,(H,29,32,33)
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n/an/a 272n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2706
PNG
(3-[7-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-8-2-4-10-20(17)30)24-25(27(33)29-26(24)32)23-18-9-3-5-11-21(18)31-14-16(13-28)7-6-12-22(23)31/h2-5,8-11,15-16H,6-7,12-14,28H2,1H3,(H,29,32,33)
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n/an/a 400n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2698
PNG
(3-{6H,7H,8H,9H,10H-azepino[1,2-a]indol-11-yl}-4-(1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H23N3O2/c1-28-15-18(16-9-4-6-11-19(16)28)23-24(26(31)27-25(23)30)22-17-10-5-7-12-20(17)29-14-8-2-3-13-21(22)29/h4-7,9-12,15H,2-3,8,13-14H2,1H3,(H,27,30,31)
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n/an/a 450n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2711
PNG
(3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CNCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H20N4O2/c1-27-13-16(14-6-2-4-8-17(14)27)21-22(24(30)26-23(21)29)20-15-7-3-5-9-18(15)28-11-10-25-12-19(20)28/h2-9,13,25H,10-12H2,1H3,(H,26,29,30)
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n/an/a 540n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2715
PNG
(3-[(2R)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2702
PNG
(3-[3-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-15(12-27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 1.10E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2710
PNG
(3-[8-Amino-7,8,9,10-tetrahydro-6H-azepino[1,2-a]in...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(N)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-12-15(27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2704
PNG
(3-[8-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-12-16(14-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 2.60E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2700
PNG
(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 2.80E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2711
PNG
(3-(1,2,3,4-Tetrahydropyrazino[1,2-a]indol-10-yl)-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CNCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H20N4O2/c1-27-13-16(14-6-2-4-8-17(14)27)21-22(24(30)26-23(21)29)20-15-7-3-5-9-18(15)28-11-10-25-12-19(20)28/h2-9,13,25H,10-12H2,1H3,(H,26,29,30)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2708
PNG
(3-{2-amino-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(N)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-11-10-14(26)12-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2699
PNG
(3-[2-(aminomethyl)-1H,2H,3H-benzo[b]pyrrolizin-9-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(11-26)10-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 3.90E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2709
PNG
(3-{3-amino-1H,2H,3H,4H-pyrido[1,2-a]indol-10-yl}-4...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(N)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(26)10-11-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2703
PNG
(3-[3-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CCN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-14-16(12-13-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 4.50E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2712
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{2-[(methylamino)meth...)
Show SMILES CNCC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21
Show InChI InChI=1S/C27H26N4O2/c1-28-14-16-11-12-31-21-10-6-4-8-18(21)23(22(31)13-16)25-24(26(32)29-27(25)33)19-15-30(2)20-9-5-3-7-17(19)20/h3-10,15-16,28H,11-14H2,1-2H3,(H,29,32,33)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
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n/an/a 5.20E+3n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2705
PNG
(3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyr...)
Show SMILES CN(C)CC1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2714
PNG
(3-[(2S)-2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3C[C@@H](CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)/t15-/m0/s1
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n/an/a 1.21E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2706
PNG
(3-[7-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-8-2-4-10-20(17)30)24-25(27(33)29-26(24)32)23-18-9-3-5-11-21(18)31-14-16(13-28)7-6-12-22(23)31/h2-5,8-11,15-16H,6-7,12-14,28H2,1H3,(H,29,32,33)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2697
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{1H,2H,3H,4H-pyrido[1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c1-27-14-17(15-8-2-4-10-18(15)27)22-23(25(30)26-24(22)29)21-16-9-3-5-11-19(16)28-13-7-6-12-20(21)28/h2-5,8-11,14H,6-7,12-13H2,1H3,(H,26,29,30)
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n/an/a 2.30E+4n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2701
PNG
(3-[2-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CCN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-11-16(10-12-28)14-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 2.40E+4n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2707
PNG
(3-[9-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-8-2-4-10-20(17)30)24-25(27(33)29-26(24)32)23-18-9-3-5-11-21(18)31-12-6-7-16(14-28)13-22(23)31/h2-5,8-11,15-16H,6-7,12-14,28H2,1H3,(H,29,32,33)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2696
PNG
(3-{1H,2H,3H-benzo[b]pyrrolizin-9-yl}-4-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H19N3O2/c1-26-13-16(14-7-2-4-9-17(14)26)21-22(24(29)25-23(21)28)20-15-8-3-5-10-18(15)27-12-6-11-19(20)27/h2-5,7-10,13H,6,11-12H2,1H3,(H,25,28,29)
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n/an/a 6.80E+4n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2713
PNG
(3-[6,7,8,9-Tetrahydro-8-[(trimethylamino)methyl]py...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(C[N+](C)(C)C)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C29H30N4O2/c1-31-16-21(19-9-5-7-11-22(19)31)26-27(29(35)30-28(26)34)25-20-10-6-8-12-23(20)32-14-13-18(15-24(25)32)17-33(2,3)4/h5-12,16,18H,13-15,17H2,1-4H3/p+1
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n/an/a 9.25E+4n/an/an/an/an/an/a



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM2698
PNG
(3-{6H,7H,8H,9H,10H-azepino[1,2-a]indol-11-yl}-4-(1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H23N3O2/c1-28-15-18(16-9-4-6-11-19(16)28)23-24(26(31)27-25(23)30)22-17-10-5-7-12-20(17)29-14-8-2-3-13-21(22)29/h4-7,9-12,15H,2-3,8,13-14H2,1H3,(H,27,30,31)
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n/an/a>1.00E+5n/an/an/an/a8.537



Roche Products Limited



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%