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PubMed code 8558522

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2341
PNG
(Isopropyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1Hp...)
Show SMILES CC(C)OC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-9(2)21-14(18)12-4-3-7-17(12)22(19,20)13-8-10(15)5-6-11(13)16/h3-9H,16H2,1-2H3
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n/an/a 270n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2339
PNG
(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C13H13ClN2O4S/c1-2-20-13(17)11-4-3-7-16(11)21(18,19)12-8-9(14)5-6-10(12)15/h3-8H,2,15H2,1H3
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n/an/a 400n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2340
PNG
(Pyrrolyl Aryl Sulfone (PAS) 8f | n-Propyl 1-[(2-Am...)
Show SMILES CCCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-2-8-21-14(18)12-4-3-7-17(12)22(19,20)13-9-10(15)5-6-11(13)16/h3-7,9H,2,8,16H2,1H3
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n/an/a 400n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2338
PNG
(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Show SMILES COC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C12H11ClN2O4S/c1-19-12(16)10-3-2-6-15(10)20(17,18)11-7-8(13)4-5-9(11)14/h2-7H,14H2,1H3
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n/an/a 450n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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n/an/a 600n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2342
PNG
(Allyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyrr...)
Show SMILES Nc1ccc(Cl)cc1S(=O)(=O)n1cccc1C(=O)OCC=C
Show InChI InChI=1S/C14H13ClN2O4S/c1-2-8-21-14(18)12-4-3-7-17(12)22(19,20)13-9-10(15)5-6-11(13)16/h2-7,9H,1,8,16H2
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n/an/a 900n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (L100I)


(Human immunodeficiency virus type 1)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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n/an/a 3.50E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2348
PNG
(Ethyl 1-[(2-Amino-5-methylphenyl)sulfonyl]-1H-pyrr...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(C)ccc1N
Show InChI InChI=1S/C14H16N2O4S/c1-3-20-14(17)12-5-4-8-16(12)21(18,19)13-9-10(2)6-7-11(13)15/h4-9H,3,15H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM2340
PNG
(Pyrrolyl Aryl Sulfone (PAS) 8f | n-Propyl 1-[(2-Am...)
Show SMILES CCCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-2-8-21-14(18)12-4-3-7-17(12)22(19,20)13-9-10(15)5-6-11(13)16/h3-7,9H,2,8,16H2,1H3
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n/an/a 5.00E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2347
PNG
(Pyrrolyl Aryl Sulfone (PAS) 8v | ethyl 1-[(5-methy...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(C)ccc1[N+]([O-])=O
Show InChI InChI=1S/C14H14N2O6S/c1-3-22-14(17)12-5-4-8-15(12)23(20,21)13-9-10(2)6-7-11(13)16(18)19/h4-9H,3H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM2338
PNG
(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Show SMILES COC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C12H11ClN2O4S/c1-19-12(16)10-3-2-6-15(10)20(17,18)11-7-8(13)4-5-9(11)14/h2-7H,14H2,1H3
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n/an/a 6.90E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (L100I)


(Human immunodeficiency virus type 1)
BDBM2338
PNG
(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Show SMILES COC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C12H11ClN2O4S/c1-19-12(16)10-3-2-6-15(10)20(17,18)11-7-8(13)4-5-9(11)14/h2-7H,14H2,1H3
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n/an/a 7.40E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM2339
PNG
(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C13H13ClN2O4S/c1-2-20-13(17)11-4-3-7-16(11)21(18,19)12-8-9(14)5-6-10(12)15/h3-8H,2,15H2,1H3
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n/an/a 7.50E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM2341
PNG
(Isopropyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1Hp...)
Show SMILES CC(C)OC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-9(2)21-14(18)12-4-3-7-17(12)22(19,20)13-8-10(15)5-6-11(13)16/h3-9H,16H2,1-2H3
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n/an/a 8.00E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (L100I)


(Human immunodeficiency virus type 1)
BDBM2339
PNG
(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C13H13ClN2O4S/c1-2-20-13(17)11-4-3-7-16(11)21(18,19)12-8-9(14)5-6-10(12)15/h3-8H,2,15H2,1H3
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n/an/a 8.50E+3n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (L100I)


(Human immunodeficiency virus type 1)
BDBM2340
PNG
(Pyrrolyl Aryl Sulfone (PAS) 8f | n-Propyl 1-[(2-Am...)
Show SMILES CCCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-2-8-21-14(18)12-4-3-7-17(12)22(19,20)13-9-10(15)5-6-11(13)16/h3-7,9H,2,8,16H2,1H3
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n/an/a 1.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM2342
PNG
(Allyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyrr...)
Show SMILES Nc1ccc(Cl)cc1S(=O)(=O)n1cccc1C(=O)OCC=C
Show InChI InChI=1S/C14H13ClN2O4S/c1-2-8-21-14(18)12-4-3-7-17(12)22(19,20)13-9-10(15)5-6-11(13)16/h2-7,9H,1,8,16H2
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n/an/a 1.40E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (L100I)


(Human immunodeficiency virus type 1)
BDBM2341
PNG
(Isopropyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1Hp...)
Show SMILES CC(C)OC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C14H15ClN2O4S/c1-9(2)21-14(18)12-4-3-7-17(12)22(19,20)13-8-10(15)5-6-11(13)16/h3-9H,16H2,1-2H3
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n/an/a 1.40E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2343
PNG
(Ethyl 1-[(5-Chloro-2-formamidophenyl)sulfonyl]-1Hp...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1NC=O
Show InChI InChI=1S/C14H13ClN2O5S/c1-2-22-14(19)12-4-3-7-17(12)23(20,21)13-8-10(15)5-6-11(13)16-9-18/h3-9H,2H2,1H3,(H,16,18)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2345
PNG
(Ethyl 1-[(5-Chloro-2-propionamidophenyl)sulfonyl]-...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1NC(=O)CC
Show InChI InChI=1S/C16H17ClN2O5S/c1-3-15(20)18-12-8-7-11(17)10-14(12)25(22,23)19-9-5-6-13(19)16(21)24-4-2/h5-10H,3-4H2,1-2H3,(H,18,20)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM2338
PNG
(Methyl 1-[(2-Amino-5-chlorophenyl)sulfonyl]-1H-pyr...)
Show SMILES COC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C12H11ClN2O4S/c1-19-12(16)10-3-2-6-15(10)20(17,18)11-7-8(13)4-5-9(11)14/h2-7H,14H2,1H3
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2344
PNG
(Ethyl 1-[(2-Acetamido-5-chlorophenyl)sulfonyl]-1Hp...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1NC(C)=O
Show InChI InChI=1S/C15H15ClN2O5S/c1-3-23-15(20)13-5-4-8-18(13)24(21,22)14-9-11(16)6-7-12(14)17-10(2)19/h4-9H,3H2,1-2H3,(H,17,19)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM2339
PNG
(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Show SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N
Show InChI InChI=1S/C13H13ClN2O4S/c1-2-20-13(17)11-4-3-7-16(11)21(18,19)12-8-9(14)5-6-10(12)15/h3-8H,2,15H2,1H3
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (Y181C)


(Human immunodeficiency virus type 1)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase


(Human immunodeficiency virus type 1)
BDBM2346
PNG
(Ethyl 1-[[5-Chloro-2-[(ethoxycarbonyl)acetamido]-p...)
Show SMILES CCOC(=O)CC(=O)Nc1ccc(Cl)cc1S(=O)(=O)n1cccc1C(=O)OCC
Show InChI InChI=1S/C18H19ClN2O7S/c1-3-27-17(23)11-16(22)20-13-8-7-12(19)10-15(13)29(25,26)21-9-5-6-14(21)18(24)28-4-2/h5-10H,3-4,11H2,1-2H3,(H,20,22)
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n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)


Article DOI: 10.1021/jm950568w
BindingDB Entry DOI: 10.7270/Q27W69D4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%