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PubMed code 8691453

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051751
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C19H25NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,15-17,19-20H,2,4,9-11H2,1,3H3
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0.110n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051753
PNG
(1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2
Show InChI InChI=1S/C20H23NO/c1-2-19(22)20-17(12-16-9-10-18(20)21-16)15-8-7-13-5-3-4-6-14(13)11-15/h3-8,11,16-18,20-21H,2,9-10,12H2,1H3
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0.220n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051757
PNG
(1-[3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C18H23NO/c1-3-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)18(15)17(20)4-2/h3,5-8,14-16,18-19H,1,4,9-11H2,2H3
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0.320n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50041293
PNG
(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2C
Show InChI InChI=1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3
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0.390n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051750
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C20H27NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,16-18,20H,2,5,10-12H2,1,3-4H3
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0.820n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50041293
PNG
(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2C
Show InChI InChI=1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3
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2.90n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051754
PNG
(1-[8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C19H25NO/c1-4-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)3)19(16)18(21)5-2/h4,6-9,15-17,19H,1,5,10-12H2,2-3H3
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3.20n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051758
PNG
(1-[3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]oct-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C19H27NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,12,15-17,19-20H,4,9-11H2,1-3H3
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5.30n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051752
PNG
(1-(3-p-Tolyl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C17H23NO/c1-3-16(19)17-14(10-13-8-9-15(17)18-13)12-6-4-11(2)5-7-12/h4-7,13-15,17-18H,3,8-10H2,1-2H3
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5.5n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051757
PNG
(1-[3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C18H23NO/c1-3-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)18(15)17(20)4-2/h3,5-8,14-16,18-19H,1,4,9-11H2,2H3
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10.9n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051752
PNG
(1-(3-p-Tolyl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C17H23NO/c1-3-16(19)17-14(10-13-8-9-15(17)18-13)12-6-4-11(2)5-7-12/h4-7,13-15,17-18H,3,8-10H2,1-2H3
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19n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50041303
PNG
(1-[3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C20H29NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,13,16-18,20H,5,10-12H2,1-4H3
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36n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051754
PNG
(1-[8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C19H25NO/c1-4-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)3)19(16)18(21)5-2/h4,6-9,15-17,19H,1,5,10-12H2,2-3H3
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78n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051749
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2
Show InChI InChI=1S/C22H31NO/c1-2-21(24)22-19(14-18-12-13-20(22)23-18)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h8-11,15,18-20,22-23H,2-7,12-14H2,1H3
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85n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051751
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C19H25NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,15-17,19-20H,2,4,9-11H2,1,3H3
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94n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051755
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-methyl-8-aza-bicyclo[...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2C
Show InChI InChI=1S/C23H33NO/c1-3-22(25)23-20(15-19-13-14-21(23)24(19)2)18-11-9-17(10-12-18)16-7-5-4-6-8-16/h9-12,16,19-21,23H,3-8,13-15H2,1-2H3
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97n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50041296
PNG
(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2C
Show InChI InChI=1S/C18H25NO/c1-4-17(20)18-15(13-7-5-12(2)6-8-13)11-14-9-10-16(18)19(14)3/h5-8,14-16,18H,4,9-11H2,1-3H3
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130n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051758
PNG
(1-[3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]oct-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C19H27NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,12,15-17,19-20H,4,9-11H2,1-3H3
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150n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051756
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-aza-bicyclo[3.2...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(N2)C1C(=O)CC
Show InChI InChI=1S/C21H31NO/c1-4-14(5-2)15-7-9-16(10-8-15)18-13-17-11-12-19(22-17)21(18)20(23)6-3/h7-10,14,17-19,21-22H,4-6,11-13H2,1-3H3
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150n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50041296
PNG
(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2C
Show InChI InChI=1S/C18H25NO/c1-4-17(20)18-15(13-7-5-12(2)6-8-13)11-14-9-10-16(18)19(14)3/h5-8,14-16,18H,4,9-11H2,1-3H3
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160n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051753
PNG
(1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2
Show InChI InChI=1S/C20H23NO/c1-2-19(22)20-17(12-16-9-10-18(20)21-16)15-8-7-13-5-3-4-6-14(13)11-15/h3-8,11,16-18,20-21H,2,9-10,12H2,1H3
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440n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50051759
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-methyl-8-aza-bi...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(C1C(=O)CC)N2C
Show InChI InChI=1S/C22H33NO/c1-5-15(6-2)16-8-10-17(11-9-16)19-14-18-12-13-20(23(18)4)22(19)21(24)7-3/h8-11,15,18-20,22H,5-7,12-14H2,1-4H3
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540n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-paroxetine from Serotonin transporter of rat frontal cortex membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051750
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C20H27NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,16-18,20H,2,5,10-12H2,1,3-4H3
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794n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051749
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2
Show InChI InChI=1S/C22H31NO/c1-2-21(24)22-19(14-18-12-13-20(22)23-18)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h8-11,15,18-20,22-23H,2-7,12-14H2,1H3
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4.30E+3n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051756
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-aza-bicyclo[3.2...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(N2)C1C(=O)CC
Show InChI InChI=1S/C21H31NO/c1-4-14(5-2)15-7-9-16(10-8-15)18-13-17-11-12-19(22-17)21(18)20(23)6-3/h7-10,14,17-19,21-22H,4-6,11-13H2,1-3H3
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5.10E+3n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50041303
PNG
(1-[3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C20H29NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,13,16-18,20H,5,10-12H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051755
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-methyl-8-aza-bicyclo[...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2C
Show InChI InChI=1S/C23H33NO/c1-3-22(25)23-20(15-19-13-14-21(23)24(19)2)18-11-9-17(10-12-18)16-7-5-4-6-8-16/h9-12,16,19-21,23H,3-8,13-15H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50051759
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-methyl-8-aza-bi...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(C1C(=O)CC)N2C
Show InChI InChI=1S/C22H33NO/c1-5-15(6-2)16-8-10-17(11-9-16)19-14-18-12-13-20(23(18)4)22(19)21(24)7-3/h8-11,15,18-20,22H,5-7,12-14H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50041293
PNG
(1-(8-Methyl-3-naphthalen-2-yl-8-aza-bicyclo[3.2.1]...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2C
Show InChI InChI=1S/C21H25NO/c1-3-20(23)21-18(13-17-10-11-19(21)22(17)2)16-9-8-14-6-4-5-7-15(14)12-16/h4-9,12,17-19,21H,3,10-11,13H2,1-2H3
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n/an/a 0.120n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051754
PNG
(1-[8-Methyl-3-(4-vinyl-phenyl)-8-aza-bicyclo[3.2.1...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2C
Show InChI InChI=1S/C19H25NO/c1-4-13-6-8-14(9-7-13)16-12-15-10-11-17(20(15)3)19(16)18(21)5-2/h4,6-9,15-17,19H,1,5,10-12H2,2-3H3
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n/an/a 0.900n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051757
PNG
(1-[3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C=C)cc1)N2
Show InChI InChI=1S/C18H23NO/c1-3-12-5-7-13(8-6-12)15-11-14-9-10-16(19-14)18(15)17(20)4-2/h3,5-8,14-16,18-19H,1,4,9-11H2,2H3
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n/an/a 1.5n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051752
PNG
(1-(3-p-Tolyl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2
Show InChI InChI=1S/C17H23NO/c1-3-16(19)17-14(10-13-8-9-15(17)18-13)12-6-4-11(2)5-7-12/h4-7,13-15,17-18H,3,8-10H2,1-2H3
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n/an/a 4.70n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051750
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-methyl-8-aza-bicyclo...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2C
Show InChI InChI=1S/C20H27NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,16-18,20H,2,5,10-12H2,1,3-4H3
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n/an/a 7.20n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50041296
PNG
(1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2C
Show InChI InChI=1S/C18H25NO/c1-4-17(20)18-15(13-7-5-12(2)6-8-13)11-14-9-10-16(18)19(14)3/h5-8,14-16,18H,4,9-11H2,1-3H3
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n/an/a 8.20n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051751
PNG
(1-[3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)=C)N2
Show InChI InChI=1S/C19H25NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,15-17,19-20H,2,4,9-11H2,1,3H3
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n/an/a 16n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051753
PNG
(1-(3-Naphthalen-2-yl-8-aza-bicyclo[3.2.1]oct-2-yl)...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc3ccccc3c1)N2
Show InChI InChI=1S/C20H23NO/c1-2-19(22)20-17(12-16-9-10-18(20)21-16)15-8-7-13-5-3-4-6-14(13)11-15/h3-8,11,16-18,20-21H,2,9-10,12H2,1H3
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n/an/a 36n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051756
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-aza-bicyclo[3.2...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(N2)C1C(=O)CC
Show InChI InChI=1S/C21H31NO/c1-4-14(5-2)15-7-9-16(10-8-15)18-13-17-11-12-19(22-17)21(18)20(23)6-3/h7-10,14,17-19,21-22H,4-6,11-13H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051759
PNG
(1-{3-[4-(1-Ethyl-propyl)-phenyl]-8-methyl-8-aza-bi...)
Show SMILES CCC(CC)c1ccc(cc1)C1CC2CCC(C1C(=O)CC)N2C
Show InChI InChI=1S/C22H33NO/c1-5-15(6-2)16-8-10-17(11-9-16)19-14-18-12-13-20(23(18)4)22(19)21(24)7-3/h8-11,15,18-20,22H,5-7,12-14H2,1-4H3
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n/an/a 270n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051755
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-methyl-8-aza-bicyclo[...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2C
Show InChI InChI=1S/C23H33NO/c1-3-22(25)23-20(15-19-13-14-21(23)24(19)2)18-11-9-17(10-12-18)16-7-5-4-6-8-16/h9-12,16,19-21,23H,3-8,13-15H2,1-2H3
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n/an/a 320n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50041303
PNG
(1-[3-(4-Isopropyl-phenyl)-8-methyl-8-aza-bicyclo[3...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2C
Show InChI InChI=1S/C20H29NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,13,16-18,20H,5,10-12H2,1-4H3
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n/an/a 440n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051749
PNG
(1-[3-(4-Cyclohexyl-phenyl)-8-aza-bicyclo[3.2.1]oct...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C1CCCCC1)N2
Show InChI InChI=1S/C22H31NO/c1-2-21(24)22-19(14-18-12-13-20(22)23-18)17-10-8-16(9-11-17)15-6-4-3-5-7-15/h8-11,15,18-20,22-23H,2-7,12-14H2,1H3
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n/an/a 490n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50051758
PNG
(1-[3-(4-Isopropyl-phenyl)-8-aza-bicyclo[3.2.1]oct-...)
Show SMILES CCC(=O)C1C2CCC(CC1c1ccc(cc1)C(C)C)N2
Show InChI InChI=1S/C19H27NO/c1-4-18(21)19-16(11-15-9-10-17(19)20-15)14-7-5-13(6-8-14)12(2)3/h5-8,12,15-17,19-20H,4,9-11H2,1-3H3
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n/an/a 540n/an/an/an/an/an/a



State University of New York

Curated by ChEMBL


Assay Description
Displacement of [125I]-RTI-55 from dopamine transporter of rat brain membranes


J Med Chem 39: 2554-8 (1996)


Article DOI: 10.1021/jm9600508
BindingDB Entry DOI: 10.7270/Q2V69HP1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%