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PubMed code 8709129

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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PubMed
0.300n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Agonistic activity at cloned human 5-hydroxytryptamine 2C receptor using [125I]-DOI as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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0.480n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Agonistic activity at cloned human 5-hydroxytryptamine 2A receptor using [125I]-DOI as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052339
PNG
(2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES NCCc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C12H14BrNO2/c13-10-9-3-6-15-11(9)7(1-4-14)8-2-5-16-12(8)10/h1-6,14H2
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0.800n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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1.15n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-rauwolscine as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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1.60n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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2.28n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Antagonistic activity at cloned human 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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4.30n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21342
PNG
((4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[...)
Show SMILES CCN(CC)C(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34
Show InChI InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of [3H]- ketanserin labelled towards Rat cortical 5-hydroxytryptamine 2A receptor using radioligand binding assay


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21342
PNG
((4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[...)
Show SMILES CCN(CC)C(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34
Show InChI InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
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5.10n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of [3H]- -8-OH-DPAT labelled towards Rat Hippocampal 5-hydroxytryptamine 1A receptor using radioligand binding assay


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052338
PNG
(2-(2,3,6,7-Tetrahydro-benzo[1,2-b;4,5-b']difuran-4...)
Show SMILES NCCc1c2CCOc2cc2CCOc12
Show InChI InChI=1S/C12H15NO2/c13-4-1-10-9-3-6-14-11(9)7-8-2-5-15-12(8)10/h7H,1-6,13H2
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5.20n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50005257
PNG
((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Show SMILES COc1cc(CC(C)N)c(OC)cc1Br
Show InChI InChI=1S/C11H16BrNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
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6.10n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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11n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Antagonistic activity at cloned human 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052337
PNG
(2-(8-bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES CC(N)Cc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO2/c1-7(15)6-10-8-2-4-17-13(8)11(14)9-3-5-16-12(9)10/h7H,2-6,15H2,1H3
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18n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50005257
PNG
((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Show SMILES COc1cc(CC(C)N)c(OC)cc1Br
Show InChI InChI=1S/C11H16BrNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
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22n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052336
PNG
(1-Methyl-2-(2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']...)
Show SMILES CC(N)Cc1c2CCOc2cc2CCOc12
Show InChI InChI=1S/C13H17NO2/c1-8(14)6-11-10-3-5-15-12(10)7-9-2-4-16-13(9)11/h7-8H,2-6,14H2,1H3
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29n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat hippocampal 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052339
PNG
(2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Show SMILES NCCc1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C12H14BrNO2/c13-10-9-3-6-15-11(9)7(1-4-14)8-2-5-16-12(8)10/h1-6,14H2
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34n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052336
PNG
(1-Methyl-2-(2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']...)
Show SMILES CC(N)Cc1c2CCOc2cc2CCOc12
Show InChI InChI=1S/C13H17NO2/c1-8(14)6-11-10-3-5-15-12(10)7-9-2-4-16-13(9)11/h7-8H,2-6,14H2,1H3
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2.01E+3n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052338
PNG
(2-(2,3,6,7-Tetrahydro-benzo[1,2-b;4,5-b']difuran-4...)
Show SMILES NCCc1c2CCOc2cc2CCOc12
Show InChI InChI=1S/C12H15NO2/c13-4-1-10-9-3-6-14-11(9)7-8-2-5-15-12(8)10/h7H,1-6,13H2
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2.30E+3n/an/an/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand


J Med Chem 39: 2953-61 (1996)


Article DOI: 10.1021/jm960199j
BindingDB Entry DOI: 10.7270/Q28914ZS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%