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PubMed code 8960550

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50054970
PNG
(CHEMBL359399 | Tetradecanoic acid (S)-2-hydroxy-1-...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H](CO)[C@@H]1CCC(=O)O1
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)25-18(16-21)17-14-15-20(23)24-17/h17-18,21H,2-16H2,1H3/t17-,18-/m0/s1
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Article
PubMed
1.07E+3n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Displacement of [3H-20] phorbol 12,13-dibutyrate(PDBU) from recombinant Protein kinase C alpha


J Med Chem 39: 4912-9 (1997)


Article DOI: 10.1021/jm960525v
BindingDB Entry DOI: 10.7270/Q27080J0
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50054969
PNG
(((S)-3-Hydroxymethyl-5-oxo-tetrahydro-furan-3-yl)-...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@]1(CO)COC(=O)C1
Show InChI InChI=1S/C21H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-25-19(23)15-21(17-22)16-20(24)26-18-21/h22H,2-18H2,1H3/t21-/m1/s1
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Article
PubMed
1.69E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Displacement of [3H-20] phorbol 12,13-dibutyrate(PDBU) from recombinant Protein kinase C alpha


J Med Chem 39: 4912-9 (1997)


Article DOI: 10.1021/jm960525v
BindingDB Entry DOI: 10.7270/Q27080J0
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50054971
PNG
(CHEMBL145502 | [(S)-3-(2-Hydroxy-ethyl)-5-oxo-tetr...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@]1(CCO)COC(=O)C1
Show InChI InChI=1S/C22H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-26-20(24)17-22(14-15-23)18-21(25)27-19-22/h23H,2-19H2,1H3/t22-/m1/s1
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Article
PubMed
1.84E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Displacement of [3H-20] phorbol 12,13-dibutyrate(PDBU) from recombinant Protein kinase C alpha


J Med Chem 39: 4912-9 (1997)


Article DOI: 10.1021/jm960525v
BindingDB Entry DOI: 10.7270/Q27080J0
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50054968
PNG
(CHEMBL144316 | [(R)-3-(2-Hydroxy-ethyl)-5-oxo-tetr...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@]1(CCO)COC(=O)C1
Show InChI InChI=1S/C22H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-26-20(24)17-22(14-15-23)18-21(25)27-19-22/h23H,2-19H2,1H3/t22-/m0/s1
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Article
PubMed
2.41E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Displacement of [3H-20] phorbol 12,13-dibutyrate(PDBU) from recombinant Protein kinase C alpha


J Med Chem 39: 4912-9 (1997)


Article DOI: 10.1021/jm960525v
BindingDB Entry DOI: 10.7270/Q27080J0
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50054972
PNG
(CHEMBL344779 | Tetradecanoic acid (S)-2-hydroxy-1-...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H](CO)[C@H]1CCC(=O)O1
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)25-18(16-21)17-14-15-20(23)24-17/h17-18,21H,2-16H2,1H3/t17-,18+/m1/s1
PDB
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Article
PubMed
2.80E+4n/an/an/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Displacement of [3H-20] phorbol 12,13-dibutyrate(PDBU) from recombinant Protein kinase C alpha


J Med Chem 39: 4912-9 (1997)


Article DOI: 10.1021/jm960525v
BindingDB Entry DOI: 10.7270/Q27080J0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%