Compile Data Set for Download or QSAR
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Found 15 Enz. Inhib. hit(s) with all data for entry = 50036553
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  700nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055662((4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055647(10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-[1...)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055646(4-Butyrylamino-1-methoxymethyl-1H-imidazole-2-carb...)
Affinity DataIC50:  2.38E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055656(10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-bu...)
Affinity DataIC50:  2.42E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055661(4-(4-Dimethylamino-butyrylamino)-1-methoxymethyl-1...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055659(2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-meth...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055649(10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-[[...)
Affinity DataIC50:  3.88E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055652(10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-ca...)
Affinity DataIC50:  4.29E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055653(10-[[[1-(Methoxymethyl)-2-[[3-(dimethylamino)propy...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055651(10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-[4...)
Affinity DataIC50:  4.82E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055650(10-[[[1-(Methoxymethyl)-2-carbethoxypyrrol-4-yl]ca...)
Affinity DataIC50:  4.84E+3nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055663(10-[[[1-(Methoxymethyl)-2-[[1-(methoxymethyl)-2-[[...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055648(10-[2-[1-(Methoxymethyl)-4-[1-(methoxymethyl)-4-bu...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50055660(1-amino-3-(4-(4-(2-(amino(iminio)methylamino)aceta...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibit supercoil relaxation property of topoisomerase I.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed