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Found 19 Enz. Inhib. hit(s) with all data for entry = 50007527
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064310(2-Ethoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d...)
Affinity DataKi:  1.40nM Kon:  0.000127M-1s-1 Koff:  9.36E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064318(2-Propoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-...)
Affinity DataKi:  1.43nM Kon:  0.000142M-1s-1 Koff:  9.93E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064316(2-Ethylsulfanyl-5,6-dimethyl-thieno[2,3-d][1,3]oxa...)
Affinity DataKi:  2.73nM Kon:  0.00358M-1s-1 Koff:  1.31E+6s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064314(5,6-Dimethyl-2-propoxy-thieno[2,3-d][1,3]oxazin-4-...)
Affinity DataKi:  4.02nM Kon:  0.0000628M-1s-1 Koff:  1.56E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064325(2-Ethoxy-5-isopropyl-thieno[2,3-d][1,3]oxazin-4-on...)
Affinity DataKi:  5.61nM Kon:  0.000429M-1s-1 Koff:  7.64E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064320(2-Ethylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thien...)
Affinity DataKi:  5.70nMAssay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064326(2-Methylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  5.74nM Kon:  0.00156M-1s-1 Koff:  2.72E+5s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064313(2-Ethoxy-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-4-o...)
Affinity DataKi:  10.7nM Kon:  0.000130M-1s-1 Koff:  1.22E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064308(2-Diethylamino-5,6,7,8-tetrahydro-benzo[4,5]thieno...)
Affinity DataKi:  16.3nM Kon:  0.0000612M-1s-1 Koff:  3.75E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064322((4-Oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-...)
Affinity DataKi:  17.9nM Kon:  0.0000292M-1s-1 Koff:  1.63E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064319(5,6-Dimethyl-2-methylsulfanyl-thieno[2,3-d][1,3]ox...)
Affinity DataKi:  35nM Kon:  0.000567M-1s-1 Koff:  1.62E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064315(2-Isopropylamino-thieno[2,3-d][1,3]oxazin-4-one | ...)
Affinity DataKi:  42nM Kon:  0.000134M-1s-1 Koff:  3.20E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064317(2-Isobutoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,...)
Affinity DataKi:  51nM Kon:  0.0000515M-1s-1 Koff:  1.01E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064324(2-Isopropylamino-5,6-dimethyl-thieno[2,3-d][1,3]ox...)
Affinity DataKi:  75.5nM Kon:  0.0000850M-1s-1 Koff:  1.13E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064311(2-Benzylsulfanyl-5,6-dimethyl-thieno[2,3-d][1,3]ox...)
Affinity DataKi:  101nM Kon:  0.000354M-1s-1 Koff:  3.54E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064309(2-Isobutoxy-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-...)
Affinity DataKi:  133nM Kon:  0.0000292M-1s-1 Koff:  219s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064321(2-isopropylamino-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  145nM Kon:  0.000201M-1s-1 Koff:  1.39E+3s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064312((5,6-Dimethyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-...)
Affinity DataKi:  238nM Kon:  0.000163M-1s-1 Koff:  6.85E+5s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Leipzig

Curated by ChEMBL
LigandPNGBDBM50064323(2-Benzylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  290nM Kon:  0.0000692M-1s-1 Koff:  239s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed