Compile Data Set for Download or QSAR
maximum 50k data
Found 49 Enz. Inhib. hit(s) with all data for entry = 50007984
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069833(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049756(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  0.160nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069852(3-Isobutyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069827(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory concentration to antagonise cation efflux in nAChR subtype human alpha3betaX, expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069834(3-Hexyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069837(3-Ethyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  0.320nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069839(3-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  0.480nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069851(3-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069848(5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin-3-...)
Affinity DataKi:  0.630nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069843(2-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  0.640nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069844(3-Fluoro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  0.690nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069841(1-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069826(2-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069829(5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-nicotinic ...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069836(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-trifluor...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069840(2-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  1.90nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069850(2-Fluoro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069830(CHEMBL84537 | Ethyl-[5-((S)-1-methyl-pyrrolidin-2-...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069828(4-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069847(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-nitro-py...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069832(CHEMBL82954 | [5-((S)-1-Methyl-pyrrolidin-2-ylmeth...)
Affinity DataKi:  20nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056148(2-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataKi:  23nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069835(4-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069838(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  35nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069849(CHEMBL412372 | [5-((S)-1-Methyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  97nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069831(2-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  451nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069845(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-2-methylsu...)
Affinity DataKi:  559nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069853(2-Iodo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyr...)
Affinity DataKi:  606nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069854(CHEMBL310893 | N,N-Diethyl-3-((S)-1-methyl-pyrroli...)
Affinity DataKi:  2.83E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069842(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-2-nitro-py...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataIC50:  640nMAssay Description:Inhibitory concentration to antagonise cation efflux in nAChR subtype human alpha3betaX, expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069833(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)
Affinity DataIC50:  2.40E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069833(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)
Affinity DataIC50:  3.20E+3nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  5.00E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069831(2-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50: >1.00E+6nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069826(2-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataEC50:  2.20E+3nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056148(2-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataEC50:  4.80E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069833(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)
Affinity DataEC50: >1.00E+6nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069827(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50:  5.95E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069835(4-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50: >1.00E+6nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50: >1.00E+6nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069828(4-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataEC50:  2.10E+3nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069837(3-Ethyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50:  1.00E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049756(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Affinity DataEC50:  750nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069843(2-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataEC50:  1.40E+3nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069840(2-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50:  2.60E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069839(3-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Affinity DataEC50:  2.30E+3nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed