Compile Data Set for Download or QSAR
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Found 12 Enz. Inhib. hit(s) with all data for entry = 50008349
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072590(CHEMBL109531 | Sodium; biphenyl-3-yl-difluoro-meth...)
Affinity DataKi:  4.90E+4nMAssay Description:Binding affinity against Protein tyrosine phosphatase-1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072593(5-(Biphenyl-3-yl-difluoro-methyl)-1-sodium-1H-tetr...)
Affinity DataKi:  9.80E+4nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072595((Biphenyl-3-yl-difluoro-methyl)-phosphonium | CHEM...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity against PTP1B as a model Protein tyrosine transferase(PTP) using fluorescein diphosphate as substrate at Km concentration (20 uM)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072597((Difluoro-naphthalen-2-yl-methyl)-phosphonium | CH...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072590(CHEMBL109531 | Sodium; biphenyl-3-yl-difluoro-meth...)
Affinity DataIC50:  1.15E+5nMAssay Description:Binding affinity against Protein tyrosine phosphatase-1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072598(CHEMBL109646 | Sodium; difluoro-naphthalen-2-yl-me...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072593(5-(Biphenyl-3-yl-difluoro-methyl)-1-sodium-1H-tetr...)
Affinity DataIC50:  1.95E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072592(1-Sodium-5-(difluoro-naphthalen-2-yl-methyl)-1H-te...)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072591(2-(Biphenyl-3-yloxy)-2-fluoro-malonic acid | CHEMB...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072596(2-Fluoro-2-(naphthalen-2-yloxy)-malonic acid | CHE...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072594(CHEMBL114030 | Sodium; biphenyl-3-yl-difluoro-acet...)
Affinity DataIC50:  4.35E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50072589(CHEMBL110361 | Sodium; difluoro-naphthalen-2-yl-ac...)
Affinity DataIC50:  6.40E+5nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate as substrate at Km concentration (20 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed