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Found 17 Enz. Inhib. hit(s) with all data for entry = 50008436
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  15nMAssay Description:The inhibitory activity of the compound was tested against thrombin (IIa)More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataKi:  675nMAssay Description:The inhibitory activity of the compound was tested against trypsinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073322(((R)-2-Cyclohexyl-1-{cyclopentyl-[(3-guanidino-pro...)
Affinity DataIC50:  110nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073311(((R)-2-Cyclohexyl-1-{cyclopentyl-[(3-guanidino-3-o...)
Affinity DataIC50:  240nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073320(((R)-2-Cyclohexyl-1-{cyclopentyl-[(3-guanidino-3-o...)
Affinity DataIC50:  240nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073323(CHEMBL121608 | {(R)-1-Cyclohexylmethyl-2-[(S)-2-(3...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073313(CHEMBL421057 | N-(3-Guanidino-3-oxo-propyl)-2-(6-m...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073319((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073315((S)-1-((R)-3-Cyclohexyl-2-ethanesulfonylamino-prop...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073312(((R)-1-{[(5-Amino-pentylcarbamoyl)-methyl]-cyclope...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073324(CHEMBL333098 | N-(3-Guanidino-3-oxo-propyl)-2-((S)...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073310(((R)-2-Cyclohexyl-1-{cyclopentyl-[(2-piperidin-4-y...)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073317(CHEMBL120029 | [(R)-1-({[3-(5-Amino-2H-[1,2,4]tria...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073321(CHEMBL421276 | [(R)-1-({[2-(5-Amino-2H-[1,2,4]tria...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073318(((R)-2-Cyclohexyl-1-{cyclopentyl-[(4-guanidinocarb...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Nv Organon Scientific Development Group

Curated by ChEMBL
LigandPNGBDBM50073314(CHEMBL331930 | [(R)-2-Cyclohexyl-1-(cyclopentyl-{[...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of thrombin (IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed