Reaction Details  Report a problem with these data
Cell Reactant:
HIV-1 Nef
Syringe Reactant:
BDBM22594
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
06/14/08
ΔG°:
-28±n/a (kJ/mole)
pH:
7±n/a
Log10Kb:
4.6
Temperature:
298.15±n/a (K)
ΔHobs :
-1.8±0.33 (kJ/mole)
Corrected for ΔHioniz:
no
Stoich. Param.:
1
ΔS° :
0.0879±n/a (kJ/mole-K)
Citation
 Betzi, S; Restouin, A; Opi, S; Arold, ST; Parrot, I; Guerlesquin, F; Morelli, X; Collette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A 104:19256-61 (2007) [PubMed]  Article
Cell React
Source:
The HIV-1 Nef core domain (residues 57-205) was expressed in Escherichia coli as glutathione S-transferase fusion proteins.
Name:
Protein Nef
Synonyms:
3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef
Type:
C-terminal core protein
Mol. Mass.:
23340.47
Organism:
Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:
P03406
Residue:
206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
  
Syringe React
Name:
BDBM22594
Synonyms:
7-methoxy-4-nitro-5-oxatricyclo[7.4.0.0^{2,6}]trideca-1(13),2(6),3,7,9,11-hexaene | Compound D15
Type:
Small organic molecule
Emp. Form.:
C13H9NO4
Mol. Mass.:
243.2149
SMILES:
COc1cc2ccccc2c2cc(oc12)[N+]([O-])=O
Structure:
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