Cell Reactant:
Trypsin
Syringe Reactant:
BDBM772
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
06/15/04
ΔG°:
-26.7±0.3 (kJ/mole)
pH:
8±n/a
Log10Kb:
3.5
Temperature:
310.25±n/a (K)
ΔH° :
-23.7±1.2 (kJ/mole)
ΔHobs :
-23.7±1.2 (kJ/mole)
Corrected for ΔHioniz:
not known
ΔS° :
0.0097±0.0023 (kJ/mole-K)
Comments:
Data taken from Talhout, R.; Engberts, J. B. F. N. Eur. J. Biochem. 2001, 268, 1554-1560.
Citation
 Talhout, RVilla, AMark, AEEngberts, JB Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin. J Am Chem Soc 125:10570-9 (2003) [PubMed]  Article
Cell React
Source:
no
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Syringe React
Source:
Synthesized
Name:
BDBM772
Synonyms:
Benzamidine | CHEMBL79897 | [amino(phenyl)methylidene]azanium | benzamidine deriv. | benzamidinium chloride
Type:
n/a
Emp. Form.:
C7H9N2
Mol. Mass.:
121.1592
SMILES:
NC(=[NH2+])c1ccccc1
Structure:
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