Reaction Details  Report a problem with these data
Cell Reactant:
Purine nucleoside phosphorylase
Syringe Reactant:
BDBM50330392
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
03/18/13
ΔG°:
-47.3±0.8 (kJ/mole)
pH:
7.4±0
Temperature:
298.15±0 (K)
Citation
 Edwards, AA; Mason, JM; Clinch, K; Tyler, PC; Evans, GB; Schramm, VL Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry 48:5226-38 (2009) [PubMed]  Article 
Cell React
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Syringe React
Name:
BDBM50330392
Synonyms:
7-(pyrrolidin-1-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL1275660 | Immucillins, 15
Type:
Small organic molecule
Emp. Form.:
C11H14N4O
Mol. Mass.:
218.2551
SMILES:
O=c1[nH]cnc2c(CN3CCCC3)c[nH]c12
Structure:
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