Cell Reactant:
Induced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327)
Syringe Reactant:
BDBM50400178
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
03/20/14
ΔG°:
-34.5±0 (kJ/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
-20.2±0 (kJ/mole)
ΔS° :
0.048±0 (kJ/mole-K)
Citation
 Zhang, ZZhao, YSong, TLiu, YLi, XSu, PXie, S Study of binding thermodynamics in the optimization of BH3 mimetics. Chem Biol Drug Des 82:394-400 (2013) [PubMed]  Article
Cell React
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [172-327]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327) | Mcl-1 (aa 172-327) | Mcl-1 (residues 172-327)
Type:
n/a
Mol. Mass.:
17768.02
Organism:
Homo sapiens (Human)
Description:
Q07820[172-327]
Residue:
156
Sequence:
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Syringe React
Name:
BDBM50400178
Synonyms:
2,3‐dihydroxy‐6‐[(4‐ methylphenyl)sulfanyl]anthracene‐9,10‐dione (Ligand 5) | CHEMBL2180318
Type:
Small organic molecule
Emp. Form.:
C21H14O4S
Mol. Mass.:
362.398
SMILES:
Cc1ccc(Sc2ccc3C(=O)c4cc(O)c(O)cc4C(=O)c3c2)cc1
Structure:
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