Reaction Details  Report a problem with these data
Cell Reactant:
Histone deacetylase 8 (HDAC8)
Syringe Reactant:
BDBM152691
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
09/14/15
ΔG°:
-36±0.4 (kJ/mole)
pH:
7.5±0
Temperature:
25±0 (K)
ΔH° :
-19±n/a (kJ/mole)
ΔHobs :
-19±2 (kJ/mole)
ΔS° :
0.059±0.001 (kJ/mole-K)
Citation
 Singh, RK; Suzuki, T; Mandal, T; Balsubramanian, N; Haldar, M; Mueller, DJ; Strode, JA; Cook, G; Mallik, S; Srivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry 53:7445-58 (2014) [PubMed]  Article
Cell React
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Syringe React
Name:
BDBM152691
Synonyms:
C7-coumarinSAHA (C7-cSAHA)
Type:
Small organic molecule
Emp. Form.:
C19H24N2O5
Mol. Mass.:
360.4043
SMILES:
Cc1cc(=O)oc2cc(NC(=O)CCCCCCCC(=O)NO)ccc12
Structure:
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