Cell Reactant:
Leucyl-tRNA synthetase K510A mutant (K510A)
Syringe Reactant:
BDBM163674
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
02/16/16
ΔG°:
-25±0.4 (kJ/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
-6.3±2 (kJ/mole)
ΔS° :
-0.06±0.01 (kJ/mole-K)
Citation
 Zhao, HPalencia, ASeiradake, EGhaemi, ZCusack, SLuthey-Schulten, ZMartinis, S Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol 10:2277-85 (2015) [PubMed]  Article
Cell React
Name:
Leucine--tRNA ligase [A132I,E138V,K510A,I952T]
Synonyms:
Leucyl-tRNA synthetase K510A mutant (K510A)
Type:
Protein
Mol. Mass.:
125339.73
Organism:
Candida albicans (Ascomycetes)
Description:
A0A1D8PS12[A132I,E138V,K510A,I952T]
Residue:
1097
Sequence:
MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFATMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREVELFGSDFSKAPIDDEDAVESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQLGIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINRLRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKKENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQNLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSPDDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLANAKELAYKEGFYNGTMLIGKYKGDKVEDAAPKVKQDLIDEGLAFVYNEPESQVISRSGDDCCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGTKLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRRDDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVRANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAILRLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGLFDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQTSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPTSLTVLVSNTFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFNRKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKIMENAVPGEPGIFIKNVE
  
Syringe React
Name:
BDBM163674
Synonyms:
AN2690-AMP
Type:
Small organic molecule
Emp. Form.:
C18H18BFN5O4
Mol. Mass.:
398.177
SMILES:
CC[C@H]1O[C@H]([C@H]2O[B-]3(OCc4cc(F)ccc34)OC12)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: