Reaction Details 
Report a problem with these data
Report a problem with these dataCell Reactant:
Nuclear receptor REV-ERBβ ligand-binding domain (REV-ERBβ-LBD)
Syringe Reactant:
BDBM231645
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
06/06/17
ΔG°:
-36.83±n/a (kJ/mole)
pH:
7.5±0
Log10Kb:
-?
Temperature:
298.15±0 (K)
ΔH° :
-104.2±0 (kJ/mole)
ΔS° :
-0.232±0 (kJ/mole-K)
Citation
Matta-Camacho, E; Banerjee, S; Hughes, TS; Solt, LA; Wang, Y; Burris, TP; Kojetin, DJ Structure of REV-ERBß ligand-binding domain bound to a porphyrin antagonist. J Biol Chem 289:20054-66 (2014) [PubMed] ArticleMore Info.:
Cell React
Name:
Nuclear receptor REV-ERBβ ligand-binding domain (REV-ERBβ-LBD)
Synonyms:
NR1D2 | NR1D2_HUMAN
Type:
Protein
Mol. Mass.:
22445.55
Organism:
Homo sapiens (Human)
Description:
Human REV-ERBβ-LBD (381-579 aa)
Residue:
199
Sequence:
HLVCPLSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP
Syringe React
Name:
BDBM231645
Synonyms:
Heme
Type:
Small organic molecule
Emp. Form.:
C34H32FeN4O4
Mol. Mass.:
616.487
SMILES:
CC1=C(CCC(O)=O)C2=[N]3C1=Cc1c(C=C)c(C)c4C=C5C(C=C)=C(C)C6=[N]5[Fe]3(n14)n1c(=C6)c(C)c(CCC(O)=O)c1=C2 |c:1,8,27,36,48,t:11,20,24|
Structure:
