Cell Reactant:
Reverse transcriptase (HIV-1 RT)(1-350)
Syringe Reactant:
BDBM2483
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
06/16/17
ΔG°:
-158±47.7 (kJ/mole)
Temperature:
298.15±0 (K)
ΔH° :
-240±n/a (kJ/mole)
ΔS° :
-0.277±0.156 (kJ/mole-K)
Citation
 Decha, PIntharathep, PUdommaneethanakit, TSompornpisut, PHannongbua, SWolschann, PParasuk, V Theoretical studies on the molecular basis of HIV-1RT/NNRTIs interactions. J Enzyme Inhib Med Chem 26:29-36 (2011) [PubMed]  Article
Cell React
Name:
Reverse transcriptase (HIV-1 RT)(aa 1-350)
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
39217.95
Organism:
Human immunodeficiency virus type 1
Description:
HIV-1 RT variant (1-350 aa)
Residue:
350
Sequence:
MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTAC
  
Syringe React
Name:
BDBM2483
Synonyms:
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one | CHEMBL223228 | DMP-266 | EFV | Efavirenz | Efavirenz (EFV) | L-743,726 | Sustiva
Type:
Small organic molecule
Emp. Form.:
C14H9ClF3NO2
Mol. Mass.:
315.675
SMILES:
FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r|
Structure:
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