Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507134
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
4.10±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507134
Synonyms:
US11046680, Example 5.0
Type:
Small organic molecule
Emp. Form.:
C21H25N9O5S2
Mol. Mass.:
547.611
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2csc(C)n2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.09,-4.06,;3.75,-3.29,;3.75,-1.75,;2.42,-.98,;2.42,.56,;1.09,-1.75,;2.18,-2.84,;-0,-2.84,;-.25,-.98,;-1.71,-1.46,;-2.19,-2.93,;-3.73,-2.93,;-4.2,-1.46,;-5.67,-.98,;-6.7,-2.13,;-8.11,-1.5,;-7.94,.03,;-9.09,1.06,;-6.44,.35,;-2.96,-.56,;-2.96,.98,;-1.62,1.75,;-.29,.98,;1.04,1.75,;-1.62,3.29,;-2.96,4.06,;-4.29,3.29,;-4.29,1.75,;-5.62,.98,;-6.96,1.75,;5.09,-.98,;6.42,-1.75,;7.76,-.98,;7.76,.56,;9.09,1.33,;6.42,1.33,;5.09,.56,)|