Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507237
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
2.60±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507237
Synonyms:
US11046680, Example 116.0
Type:
Small organic molecule
Emp. Form.:
C22H22F2N6O5S
Mol. Mass.:
520.509
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(F)cc2F)nnc1-c1ccn(C)n1 |r,wU:17.18,(-7.21,-4.48,;-5.87,-5.25,;-4.54,-4.48,;-4.54,-2.94,;-3.21,-2.17,;-1.87,-2.94,;-1.87,-4.48,;-.54,-5.25,;.79,-4.48,;-3.21,-5.25,;-3.21,-6.79,;-1.96,-7.69,;-.5,-7.22,;.84,-7.99,;.07,-9.32,;1.61,-9.32,;2.17,-7.22,;3.5,-7.99,;3.5,-9.53,;4.84,-7.22,;6.17,-7.99,;7.51,-7.22,;7.51,-5.68,;8.84,-4.91,;6.17,-4.91,;4.84,-5.68,;3.5,-4.91,;-2.44,-9.16,;-3.98,-9.16,;-4.45,-7.69,;-5.92,-7.22,;-7.16,-8.12,;-8.41,-7.22,;-7.93,-5.75,;-8.84,-4.51,;-6.39,-5.75,)|