Target
Apelin receptor
Ligand
BDBM507324
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
2.10±n/a nM
Citation
 Chen, NChen, XChen, YCheng, ACConnors, RVDeignan, JDransfield, PJDu, XFu, ZHarvey, JSHeath, JAHeumann, LVHorne, DBHouze, JKaller, MRKayser, FKhakoo, AYKopecky, DJLai, SMa, ZMedina, JCMihalic, JTNishimura, NOlson, SHPattaropong, VSwaminath, GWang, XWanska, MYang, KYeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent  US11046680 Publication Date 6/29/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM507324
Synonyms:
US11046680, Example 203.0
Type:
Small organic molecule
Emp. Form.:
C23H26F2N8O5S
Mol. Mass.:
564.565
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(n2)C(F)F)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.82,-3.4,;4.49,-2.63,;4.49,-1.09,;3.16,-.32,;3.16,1.22,;1.82,-1.09,;1.05,-2.42,;2.59,-2.42,;.49,-.32,;-.85,-1.09,;-1.32,-2.55,;-2.86,-2.55,;-3.34,-1.09,;-4.88,-1.09,;-5.78,.16,;-7.25,-.32,;-7.25,-1.86,;-5.78,-2.34,;-8.34,-2.95,;-9.82,-2.55,;-7.94,-4.44,;-2.09,-.18,;-2.09,1.36,;-3.43,2.13,;-4.76,1.36,;-6.09,2.13,;-3.43,3.67,;-2.09,4.44,;-.76,3.67,;-.76,2.13,;.58,1.36,;1.91,2.13,;5.82,-.32,;7.16,-1.09,;8.49,-.32,;8.49,1.22,;9.82,1.99,;7.16,1.99,;5.82,1.22,)|
Structure:
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