Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507324
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
2.10±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507324
Synonyms:
US11046680, Example 203.0
Type:
Small organic molecule
Emp. Form.:
C23H26F2N8O5S
Mol. Mass.:
564.565
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(n2)C(F)F)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.82,-3.4,;4.49,-2.63,;4.49,-1.09,;3.16,-.32,;3.16,1.22,;1.82,-1.09,;1.05,-2.42,;2.59,-2.42,;.49,-.32,;-.85,-1.09,;-1.32,-2.55,;-2.86,-2.55,;-3.34,-1.09,;-4.88,-1.09,;-5.78,.16,;-7.25,-.32,;-7.25,-1.86,;-5.78,-2.34,;-8.34,-2.95,;-9.82,-2.55,;-7.94,-4.44,;-2.09,-.18,;-2.09,1.36,;-3.43,2.13,;-4.76,1.36,;-6.09,2.13,;-3.43,3.67,;-2.09,4.44,;-.76,3.67,;-.76,2.13,;.58,1.36,;1.91,2.13,;5.82,-.32,;7.16,-1.09,;8.49,-.32,;8.49,1.22,;9.82,1.99,;7.16,1.99,;5.82,1.22,)|