Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507366
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
210±n/a nM
Citation
 Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent  US11046680 Publication Date 6/29/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM507366
Synonyms:
US11046680, Example 245.0
Type:
Small organic molecule
Emp. Form.:
C22H19ClN4O5S2
Mol. Mass.:
518.993
SMILES:
COc1ccc(cc1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cccs1)C(O)=O |(.7,.74,;-.63,-.03,;-1.97,.73,;-1.97,2.27,;-3.31,3.04,;-4.64,2.27,;-4.64,.73,;-3.3,-.04,;-3.3,-1.58,;-2.05,-2.48,;-.59,-2,;.5,-3.09,;.9,-4.58,;-.59,-4.18,;1.83,-2.32,;3.17,-3.09,;4.5,-2.32,;5.83,-3.09,;7.17,-2.32,;7.17,-.78,;8.5,-.01,;5.83,-.01,;4.5,-.78,;-2.53,-3.95,;-4.07,-3.95,;-4.54,-2.48,;-6.01,-2.01,;-6.49,-.55,;-8.03,-.55,;-8.5,-2.01,;-7.25,-2.91,;-5.97,3.04,;-7.31,2.27,;-5.98,4.58,)|
Structure:
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