Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507367
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
39.0±n/a nM
Citation
 Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent  US11046680 Publication Date 6/29/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM507367
Synonyms:
US11046680, Example 246.0
Type:
Small organic molecule
Emp. Form.:
C13H9F3N4OS
Mol. Mass.:
326.297
SMILES:
Nc1nnc(-c2ccc(F)s2)n1-c1ccccc1OC(F)F |(3.38,-1.55,;1.91,-2.03,;1.44,-3.49,;-.1,-3.5,;-.58,-2.03,;-2.04,-1.56,;-2.52,-.09,;-4.06,-.09,;-4.54,-1.56,;-6,-2.04,;-3.29,-2.46,;.67,-1.12,;.66,.42,;-.67,1.18,;-.67,2.72,;.66,3.5,;2,2.73,;2,1.19,;3.33,.42,;4.66,1.19,;6,.42,;4.66,2.73,)|
Structure:
Search PDB for entries with ligand similarity: