Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507396
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
3.10±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507396
Synonyms:
US11046680, Example 275.0
Type:
Small organic molecule
Emp. Form.:
C21H24ClN7O5S2
Mol. Mass.:
554.042
SMILES:
CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cc(C)[nH]n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)s1 |r,wD:3.3,2.1,(4.87,-10.07,;3.78,-8.98,;4.18,-7.49,;3.09,-6.41,;3.49,-4.92,;1.61,-6.8,;.84,-8.14,;2.38,-8.14,;.52,-5.71,;-.95,-6.19,;-1.42,-7.66,;-2.96,-7.66,;-3.44,-6.19,;-4.98,-6.19,;-5.88,-7.44,;-7.35,-6.96,;-8.59,-7.87,;-7.35,-5.42,;-5.88,-4.94,;-2.19,-5.29,;-2.19,-3.75,;-3.53,-2.98,;-4.86,-3.75,;-6.19,-2.98,;-3.53,-1.44,;-2.19,-.67,;-.86,-1.44,;-.86,-2.98,;.47,-3.75,;1.81,-2.98,;5.67,-7.1,;6.92,-8,;8.16,-7.1,;7.69,-5.63,;8.59,-4.39,;6.15,-5.63,)|