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Target
Ubiquitin carboxyl-terminal hydrolase 7
Ligand
BDBM507634
Substrate
n/a
Meas. Tech.
Evaluation of the Inhibition of USP7 by the Fluorescence Intensity (FLINT) Readings
IC50
48.6±n/a nM
Citation
 Kotschy, A; Wéber, C; Vasas, A; Molnár, B; Kiss, null; Macias, A; Murray, JB; Lewkowicz, E; Geneste, O; Chanrion, M; Demarles, D Substituted piperidines for the treatment of cancer US Patent  US11046681 Publication Date 6/29/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 7
Synonyms:
Deubiquitinating enzyme 7 | HAUSP | Herpesvirus-associated ubiquitin-specific protease | UBP7_HUMAN | USP7 | Ubiquitin thioesterase 7 | Ubiquitin-specific-processing protease 7
Type:
PROTEIN
Mol. Mass.:
128274.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469483
Residue:
1102
Sequence:
MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
  
Inhibitor
Name:
BDBM507634
Synonyms:
7-(4-chlorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-1-methyl-3-phenyl-piperidine-4-carbonyl]-4-piperidyl]methyl]pyrrolo[2,3-d]pyrimidin-4-one | US11046681, Example 153
Type:
Small organic molecule
Emp. Form.:
C31H34ClN5O3
Mol. Mass.:
560.086
SMILES:
CN1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccc(Cl)cc2)CC1 |r|
Structure:
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