Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM507700
Substrate
n/a
Meas. Tech.
IRAK4 Biochemical Assay
IC50
1.000±n/a nM
Citation
 Ammann, SBacon, EMBrizgys, GChin, EChou, CCottell, JJNdukwe, MShatskikh, MTaylor, JGWright, NEYang, ZZipfel, SM Thiadiazole IRAK4 compounds US Patent  US11046686 Publication Date 6/29/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM507700
Synonyms:
(R)-7-(5-(5-(3- hydroxypyrrolidine-1- carbonyl)-1,3,4- thiadiazol-2-yl)-4- (isopropylamino)pyridin- 2-yl)pyrrolo[1,2- b]pyridazine-3- carbonitrile | US11046686, Example 17 | US11702414, Example 17
Type:
Small organic molecule
Emp. Form.:
C23H22N8O2S
Mol. Mass.:
474.538
SMILES:
CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1)-c1ccc2cc(cnn12)C#N |r|
Structure:
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