Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM507711
Substrate
n/a
Meas. Tech.
IRAK4 Biochemical Assay
IC50
1.70±n/a nM
Citation
 Ammann, SBacon, EMBrizgys, GChin, EChou, CCottell, JJNdukwe, MShatskikh, MTaylor, JGWright, NEYang, ZZipfel, SM Thiadiazole IRAK4 compounds US Patent  US11046686 Publication Date 6/29/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM507711
Synonyms:
7-(5-(5-(1H-pyrrol-1- yl)-1,3,4-thiadiazol- 2-yl)-4- (isopropylamino) pyridin-2-yl) pyrrolo[1,2- b]pyridazine-3- carbonitrile | US11046686, Example 28 | US11702414, Example 28
Type:
Small organic molecule
Emp. Form.:
C22H18N8S
Mol. Mass.:
426.497
SMILES:
CC(C)Nc1cc(ncc1-c1nnc(s1)-n1cccc1)-c1ccc2cc(cnn12)C#N
Structure:
Search PDB for entries with ligand similarity: