Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507742
Substrate
n/a
Meas. Tech.
Malachite Green Assay
IC50
<200±n/a nM
Citation
 Alam, MCleary, LFleury, MPei, ZSteel, RSutton, JKnox, JENewby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507742
Synonyms:
1-(7-chloro-1-(3-fluorophenyl)-2-oxo- 1,2-dihydroquinazolin-4-yl)azetidine-3- carbonitrile | US11046691, Compound 82 | US11084798, Cpd No 82 | US11130759, Cpd. No. 82
Type:
Small organic molecule
Emp. Form.:
C18H12ClFN4O
Mol. Mass.:
354.765
SMILES:
Fc1cccc(c1)-n1c2cc(Cl)ccc2c(nc1=O)N1CC(C1)C#N
Structure:
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