Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507778
Substrate
n/a
Meas. Tech.
Malachite Green Assay
IC50
<200±n/a nM
Citation
 Alam, MCleary, LFleury, MPei, ZSteel, RSutton, JKnox, JENewby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507778
Synonyms:
7-bromo-4-(dimethylamino)-1-phenyl- quinazolin-2(1H)-one | US11046691, Compound 34 | US11084798, Cpd No 34 | US11130759, Cpd. No. 34
Type:
Small organic molecule
Emp. Form.:
C16H14BrN3O
Mol. Mass.:
344.206
SMILES:
CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12
Structure:
Search PDB for entries with ligand similarity: