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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507785
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507785
Synonyms:
7-bromo-6-chloro-1-(2-chlorophenyl)- 4-(isoxazol-4-ylamino)hydroquinazolin- 2-one | US11046691, Compound 412 | US11084798, Cpd No 412 | US11130759, Cpd. No. 412
Type:
Small organic molecule
Emp. Form.:
C17H9BrCl2N4O2
Mol. Mass.:
452.089
SMILES:
Clc1cc2c(Nc3cnoc3)nc(=O)n(-c3ccccc3Cl)c2cc1Br |(-4.55,1.77,;-3.22,1,;-1.89,1.77,;-.55,1,;.78,1.77,;.78,3.31,;2.12,4.08,;3.52,3.45,;4.55,4.6,;3.78,5.93,;2.28,5.61,;2.12,1,;2.12,-.54,;3.45,-1.31,;.78,-1.31,;.78,-2.85,;2.12,-3.62,;2.12,-5.16,;.78,-5.93,;-.55,-5.16,;-.55,-3.62,;-1.89,-2.85,;-.55,-.54,;-1.89,-1.31,;-3.22,-.54,;-4.55,-1.31,)|
Structure:
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