Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507943
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, MCleary, LFleury, MPei, ZSteel, RSutton, JKnox, JENewby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507943
Synonyms:
7-cyclopropyl-4-(methylamino)-1-(2- methylphenyl)hydroquinazolin-2-one | US11046691, Compound 352 | US11084798, Cpd No 352 | US11130759, Cpd. No. 352
Type:
Small organic molecule
Emp. Form.:
C19H19N3O
Mol. Mass.:
305.3737
SMILES:
CNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C1CC1 |(.77,5,;2.1,4.23,;2.1,2.69,;3.44,1.93,;3.44,.38,;4.77,-.38,;2.1,-.38,;2.1,-1.93,;3.44,-2.69,;3.44,-4.23,;2.1,-5,;.77,-4.23,;.77,-2.69,;-.56,-1.93,;.77,.38,;-.56,-.38,;-1.9,.38,;-1.9,1.93,;-.56,2.69,;.77,1.93,;-3.23,-.38,;-4.77,-.38,;-4,-1.72,)|
Structure:
Search PDB for entries with ligand similarity: