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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507990
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507990
Synonyms:
1-(3-methyl(2-pyridyl))-4-(methyl- amino)-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one | US11046691, Compound 260 | US11084798, Cpd No 260 | US11130759, Cpd. No. 260
Type:
Small organic molecule
Emp. Form.:
C15H12F3N5O
Mol. Mass.:
335.2839
SMILES:
CNc1nc(=O)n(-c2ncccc2C)c2nc(ccc12)C(F)(F)F |(2.67,5,;1.33,4.23,;1.33,2.69,;2.67,1.93,;2.67,.38,;4,-.38,;1.33,-.38,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.93,;,.38,;-1.33,-.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;-4,-.38,;-5.33,.39,;-4,-1.92,;-5.33,-1.15,)|
Structure:
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