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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508019
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508019
Synonyms:
1-(2-chlorophenyl)-4-(((1s,3s)-3- methoxycyclobutyl)amino)-7-(trifluoro- methyl)pyrido[2,3-d]pyrimidin-2(1H)- one | US11046691, Compound 270 | US11084798, Cpd No 270 | US11130759, Cpd. No. 270
Type:
Small organic molecule
Emp. Form.:
C19H16ClF3N4O2
Mol. Mass.:
424.804
SMILES:
CO[C@@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F |r,wU:4.6,2.1,(4.94,6.7,;4.94,5.16,;3.61,4.39,;2.12,4.79,;1.72,3.31,;3.21,2.91,;.39,2.54,;.39,1,;1.72,.23,;1.72,-1.31,;3.06,-2.08,;.39,-2.08,;.39,-3.62,;-.94,-4.39,;-.94,-5.93,;.39,-6.7,;1.72,-5.93,;1.72,-4.39,;3.06,-3.62,;-.94,-1.31,;-2.28,-2.08,;-3.61,-1.31,;-3.61,.23,;-2.28,1,;-.94,.23,;-4.94,-2.08,;-6.28,-1.31,;-4.94,-3.62,;-6.28,-2.85,)|
Structure:
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