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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508136
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508136
Synonyms:
3-((2-oxo-1-(o-tolyl)-7-(trifluoro- methyl)-1,2-dihydroquinazolin-4-yl)- amino)propane-1-sulfonamide | US11046691, Compound 446 | US11084798, Cpd No 446 | US11130759, Cpd. No. 446
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O3S
Mol. Mass.:
440.439
SMILES:
Cc1ccccc1-n1c2cc(ccc2c(NCCCS(N)(=O)=O)nc1=O)C(F)(F)F |(3.33,-4.62,;4.67,-3.85,;6,-4.62,;7.34,-3.85,;7.34,-2.31,;6,-1.54,;4.67,-2.31,;3.33,-1.54,;3.33,,;4.67,.77,;4.67,2.31,;3.33,3.08,;2,2.31,;2,.77,;.67,,;-.67,.77,;-2,,;-3.33,.77,;-4.67,,;-6,.77,;-6,-.77,;-7.34,,;-6,2.31,;.67,-1.54,;2,-2.31,;2,-3.85,;6,3.08,;7.34,2.31,;6,4.62,;6,1.54,)|
Structure:
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