Target
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Ligand
BDBM424689
Substrate
n/a
Meas. Tech.
TYK2 JH2 Domain Binding Assay
Kd
<0.2±n/a nM
Citation
 Masse, CEGreenwood, JRMondal, SCowen, SDMcLean, TH TYK2 inhibitors and uses thereof US Patent  US11046698 Publication Date 6/29/2021 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
36941.98
Organism:
Homo sapiens (Human)
Description:
P29597 (aa 556-888)
Residue:
333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
  
Inhibitor
Name:
BDBM424689
Synonyms:
BDBM424792 | US10508120, Compound I-1193 | US10577373, Compound I-1296 | US11046698, Compound I-1193
Type:
Small organic molecule
Emp. Form.:
C24H31N7O4
Mol. Mass.:
481.5474
SMILES:
CNc1cc(Nc2cccn([C@H]3CCC[C@@H](O)C3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC |r|
Structure:
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