Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508493
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
1.40±n/a nM
Citation
 Miyazaki, SInui, MKurosaki, YYamamoto, YIzumi, MSoma, KPinkerton, AKishida, M Sulfonamide compounds US Patent  US11046710 Publication Date 6/29/2021 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM508493
Synonyms:
US11046710, Example 37
Type:
Small organic molecule
Emp. Form.:
C18H15ClF3N3O6S
Mol. Mass.:
493.841
SMILES:
O[C@@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC(F)(F)F)cc3C(=O)N2C1 |r|
Structure:
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