Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508499
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
2.00±n/a nM
Citation
 Miyazaki, SInui, MKurosaki, YYamamoto, YIzumi, MSoma, KPinkerton, AKishida, M Sulfonamide compounds US Patent  US11046710 Publication Date 6/29/2021 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM508499
Synonyms:
5-chloro-N-[(9aR)-8,8-difluoro-5-oxo-8,9,9a,10-tetrahydro-5H,7H-pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-3-yl]-2-methoxybenzenesulfonamide | US11046710, Example 45
Type:
Small organic molecule
Emp. Form.:
C18H16ClF2N3O5S
Mol. Mass.:
459.852
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CC(F)(F)CN3C(=O)c2c1 |r|
Structure:
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