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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508512
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
0.600±n/a nM
Citation
 Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent  US11046710 Publication Date 6/29/2021 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM508512
Synonyms:
2-ethoxy-5-fluoro-N-[(10aS)-7-oxo-7,8,10a,11-tetrahydro-5H,10H-[1,4]oxazino[3,4-c]pyrido[3,2-f][1,4]oxazepin-3-yl]benzenesulfonamide | US11046710, Example 61
Type:
Small organic molecule
Emp. Form.:
C19H20FN3O6S
Mol. Mass.:
437.442
SMILES:
CCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3COC(=O)CN3Cc2c1 |r|
Structure:
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