Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM508514
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
1.80±n/a nM
Citation
Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent US11046710 Publication Date 6/29/2021
More Info.:
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Inhibitor
Name:
BDBM508514
Synonyms:
5-chloro-2-methoxy-N-[(10aS)-9-methyl-7-oxo-7,8,9,10,10a, 11-hexahydro-5H-pyrazino[2,1-c]pyrido[3,2-f][1,4]oxazepin-3-yl]benzenesulfonamide | US11046710, Example 64
Type:
Small organic molecule
Emp. Form.:
C18H19ClN4O5S
Mol. Mass.:
438.885
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CNC(=O)CN3Cc2c1 |r|