Target
Adenosine receptor A2a
Ligand
BDBM508649
Substrate
n/a
Meas. Tech.
competition binding assay
Ki
12.0±n/a nM
Citation
 Amjad, AGallo, GVHenderson, TJKuang, RLim, YLo, MMMetzger, Ede Lera Ruiz, MStamford, ATempest, PWhitehead, BWu, H 2,2-difluorodioxolo A2A receptor antagonists US Patent  US11046714 Publication Date 6/29/2021 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM508649
Synonyms:
2,2-difluoro-8-{(2S)-2-[(3R or 3S)- 3-fluoro-3-methylpiperidin-1- yl]propyl}[1,3] dioxolo[4,5-h] [1,2,4]triazolo[1,5-c]quinazolin- 5-amine (faster eluting a) | US11046714, Example 89 | US11046714, Example 90
Type:
Small organic molecule
Emp. Form.:
C19H21F3N6O2
Mol. Mass.:
422.4042
SMILES:
C[C@@H](Cc1nc2c3ccc4OC(F)(F)Oc4c3nc(N)n2n1)N1CCCC(C)(F)C1 |r|
Structure:
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