Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM517319
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
1.40±n/a nM
Citation
 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US11104690 Publication Date 8/31/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM517319
Synonyms:
3-[3- (difluoromethoxy)phenyl]- N-(1,1- dioxidotetrahydrothiophen- 3-yl)-1-(4-fluorophenyl)- 1H-indazole-6-carboxamide (enantiomer A) | US11104690, Example 136-A
Type:
Small organic molecule
Emp. Form.:
C25H20F3N3O4S
Mol. Mass.:
515.504
SMILES:
FC(F)Oc1cccc(c1)-c1nn(-c2ccc(F)cc2)c2cc(ccc12)C(=O)N[C@@H]1CCS(=O)(=O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: